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J Appl Physiol 85: 1135-1141, 1998;
8750-7587/98 $5.00
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Vol. 85, Issue 3, 1135-1141, September 1998

Laryngeal-receptor responses to phasic CO2 in anesthetized cats

A. Bradford1, D. McKeogh2, and R. G. O'Regan2

1 Department of Physiology, Royal College of Surgeons in Ireland, and 2 Department of Human Anatomy and Physiology, University College Dublin, Dublin 2, Ireland

We compared the effects of CO2 applied continuously and during expiration on laryngeal-receptor activity in paralyzed, artificially ventilated and nonparalyzed, spontaneously breathing cats by using an isolated larynx, artificially ventilated to approximate a normal respiratory cycle. The majority of quiescent negative-pressure and all cold receptors were excited by 5 and 9% CO2 applied both continuously and during expiration. In general, quiescent positive-pressure, tonic negative-pressure, and tonic positive-pressure receptors were inhibited by 5 and 9% CO2 applied continuously and during expiration. There were no significant differences between responses to 5 and 9% CO2 or to continuous and expired CO2 or between paralyzed and nonparalyzed preparations. In conclusion, laryngeal receptors respond to changes in CO2 concentration occurring during a normal respiratory cycle. Because laryngeal-receptor stimulation exerts reflex effects on ventilation and upper airway muscle activity, these results suggest that airway CO2 plays a role in reflex regulation of breathing and upper airway patency.

larynx; superior laryngeal nerve; carbon dioxide


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