| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Pulmonary and Critical Care Medicine, Edward Hines, Jr., Veterans Administration Hospital, and Loyola University of Chicago Stritch School of Medicine, Hines, Illinois 60141
While sustaining a load that leads to task failure, it is unclear whether diaphragmatic fatigue develops progressively or occurs only at task failure. We hypothesized that incremental loading produces a progressive decrease in diaphragmatic contractility ever before task failure. Ten subjects generated 60% of maximal transdiaphragmatic pressure (Pdimax) for 2 min, 4 min, and until task failure. Before loading, 20 min after each period of loading, and ~20 h after the last period of loading, Pdimax, nonpotentiated and potentiated Pdi twitch pressure (Pditw), and the pattern of respiratory muscle recruitment during a CO2 challenge were recorded. Sensation of inspiratory effort at the 4th min of the task-failure protocol was greater than at the same time in the preceding 4-min protocol. Surprisingly, potentiated Pditw and Pdimax were reduced after 2 min of loading and decreased further after 4 min of loading and after task failure; nonpotentiated Pditw was reduced after 4 min of loading and after task failure. The gastric pressure contribution to tidal breathing during a CO2 challenge decreased progressively in relation to duration of the preceding loading period, whereas expiratory muscle recruitment progressively increased. A rest period of ~20 h after task failure was not sufficient to normalize these alterations in respiratory muscle recruitment or fatigue-induced changes in diaphragmatic contractility. In conclusion, while sustaining a mechanical load, the diaphragm progressively fatigued, ever before task failure, and when challenged the rib cage-to-diaphragmatic contribution to tidal breathing and recruitment of the expiratory muscles increased pari passu with duration of the preceding loading.
transdiaphragmatic twitch pressure; twitch potentiation; carbon dioxide rebreathing
This article has been cited by other articles:
|
|
 |
|
  S. Parthasarathy, A. Jubran, F. Laghi, and M. J. Tobin Sternomastoid, rib cage, and expiratory muscle activity during weaning failure J Appl Physiol, July 1, 2007; 103(1): 140 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Simpson and S. Iscoe Cardiorespiratory failure in rat induced by severe inspiratory resistive loading J Appl Physiol, April 1, 2007; 102(4): 1556 - 1564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Z. Ross, N. Middleton, R. Shave, K. George, and A. Nowicky Human, Environmental & Exercise: Corticomotor excitability contributes to neuromuscular fatigue following marathon running in man Exp Physiol, March 1, 2007; 92(2): 417 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Mador, O. Deniz, A. Aggarwal, M. Shaffer, T. J. Kufel, and C. M. Spengler Effect of Respiratory Muscle Endurance Training in Patients With COPD Undergoing Pulmonary Rehabilitation Chest, September 1, 2005; 128(3): 1216 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Saey, A. Michaud, A. Couillard, C. H. Cote, M. J. Mador, P. LeBlanc, J. Jobin, and F. Maltais Contractile Fatigue, Muscle Morphometry, and Blood Lactate in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1109 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Laghi, W. E. Langbein, A. Antonescu-Turcu, A. Jubran, C. Bammert, and M. J. Tobin Respiratory and Skeletal Muscles in Hypogonadal Men with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 598 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Mador, E. Bozkanat, A. Aggarwal, M. Shaffer, and T. J. Kufel Endurance and Strength Training in Patients With COPD Chest, June 1, 2004; 125(6): 2036 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Simpson, J. Van Eyk, and S. Iscoe Respiratory muscle injury, fatigue and serum skeletal troponin I in rat J. Physiol., February 1, 2004; 554(3): 891 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Road, T.-X. Jiang, W. D. Reid, F. Laghi, and M. J. Tobin Weaning Failure, Muscle Injury, and Fatigue Am. J. Respir. Crit. Care Med., December 15, 2003; 168(12): 1539 - 1540. [Full Text]
|
|
|
|
 |
|
 C. Roussos and A. Koutsoukou Respiratory failure Eur. Respir. J., November 16, 2003; 22(47_suppl): 3S - 14s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Saey, R. Debigare, P. LeBlanc, M. J. Mador, C. H. Cote, J. Jobin, and F. Maltais Contractile Leg Fatigue after Cycle Exercise: A Factor Limiting Exercise in Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., August 15, 2003; 168(4): 425 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Laghi and M. J. Tobin Disorders of the Respiratory Muscles Am. J. Respir. Crit. Care Med., July 1, 2003; 168(1): 10 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Mador, O. Deniz, A. Aggarwal, and T. J. Kufel Quadriceps Fatigability after Single Muscle Exercise in Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., July 1, 2003; 168(1): 102 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Mador, E. Bozkanat, and T. J. Kufel Quadriceps Fatigue After Cycle Exercise in Patients With COPD Compared With Healthy Control Subjects Chest, April 1, 2003; 123(4): 1104 - 1111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S Sprague and P. D Hopkins Use of Inspiratory Strength Training to Wean Six Patients Who Were Ventilator-Dependent Physical Therapy, February 1, 2003; 83(2): 171 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Laghi, S. E. Cattapan, A. Jubran, S. Parthasarathy, P. Warshawsky, Y.-S. A. Choi, and M. J. Tobin Is Weaning Failure Caused by Low-Frequency Fatigue of the Diaphragm? Am. J. Respir. Crit. Care Med., January 15, 2003; 167(2): 120 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.J. Kufel, L.A. Pineda, R.G. Junega, R. Hathwar, and M.J. Mador Diaphragmatic function after intense exercise in congestive heart failure patients Eur. Respir. J., December 1, 2002; 20(6): 1399 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Gandevia Spinal and Supraspinal Factors in Human Muscle Fatigue Physiol Rev, October 1, 2001; 81(4): 1725 - 1789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. SINDERBY, J. SPAHIJA, and J. BECK Changes in Respiratory Effort Sensation Over Time Are Linked to the Frequency Content of Diaphragm Electrical Activity Am. J. Respir. Crit. Care Med., March 15, 2001; 163(4): 905 - 910. [Abstract] [Full Text]
|
|
|
|
|
|
M. J. MADOR, T. J. KUFEL, L. A. PINEDA, A. STEINWALD, A. AGGARWAL, A. M. UPADHYAY, and M. A. KHAN Effect of Pulmonary Rehabilitation on Quadriceps Fatiguability during Exercise Am. J. Respir. Crit. Care Med., March 15, 2001; 163(4): 930 - 935. [Abstract] [Full Text]
|
|
|
|
|
|
M. JEFFERY MADOR, T. J. KUFEL, and L. A. PINEDA Quadriceps and Diaphragmatic Function after Exhaustive Cycle Exercise in the Healthy Elderly Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1760 - 1766. [Abstract] [Full Text]
|
|
|
|
|
|
U. Hatipoglu, F. LAGHI, and M. J. TOBIN Does Inhaled Albuterol Improve Diaphragmatic Contractility in Patients with Chronic Obstructive Pulmonary Disease? Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 1916 - 1921. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
