Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 85: 747-750, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tonkovic-Capin, M.
Right arrow Articles by Zuperku, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tonkovic-Capin, M.
Right arrow Articles by Zuperku, E. J.
Vol. 85, Issue 2, 747-750, August 1998

SPECIAL COMMUNICATION
Improved method of canine decerebration

Mislav Tonkovic-Capin, Mirko Krolo, Eckehard A. E. Stuth, Francis A. Hopp, and Edward J. Zuperku

Zablocki Department of Veterans Affairs Medical Center, and Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53295

We describe an improved decerebration method for dogs that is suitable for studies of brain stem neurons in the absence of anesthesia. Previously reported techniques of canine decerebration often lead to respiratory and hemodynamic instability and lack of typical decerebrate rigidity. We have developed a precise, visually controlled, midcollicular brain stem transection technique that overcomes these problems. Our method results in only moderate blood loss while preserving carotid and basilar artery circulations. Consistent levels of brain stem transection routinely lead to stable postdecerebration hemodynamic parameters, allowing prolonged brain stem neuronal recordings. The same model should also be useful for a variety of studies involving other physiological systems in dogs in the absence of anesthesia and for studies of anesthetic effects.

dogs; brain stem neurons; respiratory neurons; midcollicular decerebration; decerebrate rigidity


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
I. F. Brandes, E. J. Zuperku, A. G. Stucke, D. Jakovcevic, F. A. Hopp, and E. A. E. Stuth
Serotonergic Modulation of Inspiratory Hypoglossal Motoneurons in Decerebrate Dogs
J Neurophysiol, June 1, 2006; 95(6): 3449 - 3459.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Krolo, V. Tonkovic-Capin, A. G. Stucke, E. A. Stuth, F. A. Hopp, C. Dean, and E. J. Zuperku
Subtype Composition and Responses of Respiratory Neurons in the Pre-Botzinger Region to Pulmonary Afferent Inputs in Dogs
J Neurophysiol, May 1, 2005; 93(5): 2674 - 2687.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Tonkovic-Capin, A. G. Stucke, E. A. Stuth, M. Tonkovic-Capin, F. A. Hopp, D. R. McCrimmon, and E. J. Zuperku
Differential Processing of Excitation by GABAergic Gain Modulation in Canine Caudal Ventral Respiratory Group Neurons
J Neurophysiol, February 1, 2003; 89(2): 862 - 870.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Tonkovic-Capin, A. G. Stucke, E. A. Stuth, M. Tonkovic-Capin, M. Krolo, F. A. Hopp, D. R. McCrimmon, and E. J. Zuperku
Differential Modulation of Respiratory Neuronal Discharge Patterns by GABAA Receptor and Apamin-Sensitive K+ Channel Antagonism
J Neurophysiol, November 1, 2001; 86(5): 2363 - 2373.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online