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J Appl Physiol 85: 593-600, 1998;
8750-7587/98 $5.00
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Vol. 85, Issue 2, 593-600, August 1998

Bed rest decreases mechanically induced myofiber wounding and consequent wound-mediated FGF release

Mark S. F. Clarke1, Marcas M. Bamman2, and Daniel L. Feeback3

1 Division of Space Life Sciences, Universities Space Research Association and 3 Life Sciences Research Laboratories, National Aeronautics and Space Administration/Johnson Space Center, Houston, Texas 77058; and 2 Department of Human Studies, University of Alabama, Birmingham, Alabama 35294

Using a terrestrial model of spaceflight (i.e., bed rest), we investigated the amount of myofiber wounding and fibroblast growth factor (FGF) release that occurs during unloading. Myofiber wounding was determined by serum levels of the creatine kinase MM (CKMM) isoform before and after bed rest. Serum levels of both acidic FGF (aFGF) and basic FGF were also determined. A second group of subjects was treated in an identical fashion except that they underwent a resistive exercise program during bed rest. Bed rest alone caused significant (P < 0.05; n = 7) reductions in post-bed-rest serum levels of both CKMM and aFGF, which were paralleled by a significant (P < 0.05; n = 7) decrease in myofiber size. In contrast, bed rest plus resistive exercise resulted in significant (P < 0.05; n = 7) increases in post-bed-rest serum levels of both CKMM and aFGF, which were paralleled by inhibition of the atrophic response. These results suggest that mechanically induced, myofiber wound-mediated FGF release may play an important role in the etiology of unloading-induced skeletal muscle atrophy.

human; skeletal muscle; atrophy; sarcolemma; mechanical


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