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1 Department of Pulmonary Diseases, University Hospital Nijmegen, 6500 HB Nijmegen, The Netherlands; and 2 Departments of Anesthesiology and of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota 55905
The effects of the
2-adrenoceptor agonist
salbutamol (Slb) on isometric and isotonic contractile properties of
the rat diaphragm muscle
(Diamus) were examined. A
loading dose of 25 µg/kg Slb was administered intracardially before
Diamus excision to ensure adequate
diffusion. Studies were then performed with 0.05 µM
Slb in the in vitro tissue chamber. cAMP levels were determined by radioimmunoassay. Compared with controls (Ctl), cAMP levels were elevated after Slb treatment. In Slb-treated rats, isometric twitch and
maximum tetanic force were increased by ~40 and ~20%,
respectively. Maximum shortening velocity increased by ~15% after
Slb treatment, and maximum power output increased by ~25%. During
repeated isotonic activation, the rate of fatigue was faster in the
Slb-treated Diamus, but both
Slb-treated and Ctl Diamus
fatigued to the same maximum power output. Still, endurance time during
repetitive isotonic contractions was ~10% shorter in the Slb-treated
Diamus. These results are
consistent with the hypothesis that -adrenoceptor stimulation by Slb
enhances Diamus contractility and
that these effects of Slb are likely mediated, at least in part, by
elevated cAMP.
2-adrenoceptor agonist; skeletal muscle; velocity of shortening; fatigue; cAMP
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