Journal of Applied Physiology Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 85: 478-483, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bruton, J. D.
Right arrow Articles by Westerblad, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bruton, J. D.
Right arrow Articles by Westerblad, H.
Vol. 85, Issue 2, 478-483, August 1998

Effects of CO2-induced acidification on the fatigue resistance of single mouse muscle fibers at 28°C

Joseph D. Bruton, Jan Lännergren, and Håkan Westerblad

Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden

The role of reduced muscle pH in the development of skeletal muscle fatigue is unclear. This study investigated the effects of lowering skeletal muscle intracellular pH by exposure to 30% CO2 on the number of isometric tetani needed to induce significant fatigue. Isolated single mouse muscle fibers were stimulated repetitively at intervals of 4-2.5 s by using 80-Hz, 400-ms tetani at 28°C in Tyrode solution bubbled with either 5 or 30% CO2. Stimulation continued until tetanic force had fallen to 40% of the initial value. Exposure to 30% CO2 caused a significant fall in intracellular pH of ~0.3 pH unit but did not cause any significant changes in initial peak tetanic force. During the course of repetitive stimulation, intracellular pH fell by ~0.3 pH unit in both normal and acidified fibers. The number of tetani needed to reduce force to 40% of the initial value was not significantly different in 5 and 30% CO2 Tyrode. The sole effect of acidosis was to reduce the rate of relaxation of force, especially in fatigued fibers. It is concluded that, at 28°C, acidosis per se does not accelerate the development of fatigue during repeated tetanic stimulation of isolated mouse skeletal muscle fibers.

muscle fatigue; muscle contraction; relaxation rate


This article has been cited by other articles:


Home page
 J. Physiol.Home page
N. Place, T. Yamada, S.-J. Zhang, Håk. Westerblad, and J. D. Bruton
High temperature does not alter fatigability in intact mouse skeletal muscle fibres
J. Physiol., October 1, 2009; 587(19): 4717 - 4724.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. M. Handy and N. Soni
Physiological effects of hyperchloraemia and acidosis
Br. J. Anaesth., August 1, 2008; 101(2): 141 - 150.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Amann and J. A. L. Calbet
Convective oxygen transport and fatigue
J Appl Physiol, March 1, 2008; 104(3): 861 - 870.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. H. Fitts
The cross-bridge cycle and skeletal muscle fatigue
J Appl Physiol, February 1, 2008; 104(2): 551 - 558.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. G. Allen, G. D. Lamb, and H. Westerblad
Skeletal Muscle Fatigue: Cellular Mechanisms
Physiol Rev, January 1, 2008; 88(1): 287 - 332.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. G. Allen, G. D. Lamb, and H. Westerblad
Impaired calcium release during fatigue
J Appl Physiol, January 1, 2008; 104(1): 296 - 305.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Amann and J. A. Dempsey
Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance
J. Physiol., January 1, 2008; 586(1): 161 - 173.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. D. Bruton, N. Place, T. Yamada, J. P. Silva, F. H. Andrade, A. J. Dahlstedt, S.-J. Zhang, A. Katz, N.-G. Larsson, and H. Westerblad
Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice
J. Physiol., January 1, 2008; 586(1): 175 - 184.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Cifelli, F. Bourassa, L. Gariepy, K. Banas, M. Benkhalti, and J.-M. Renaud
KATP channel deficiency in mouse flexor digitorum brevis causes fibre damage and impairs Ca2+ release and force development during fatigue in vitro
J. Physiol., July 15, 2007; 582(2): 843 - 857.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Katayama, M. Amann, D. F. Pegelow, A. J. Jacques, and J. A. Dempsey
Effect of arterial oxygenation on quadriceps fatigability during isolated muscle exercise
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1279 - R1286.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Sahlin, J. S. Nielsen, M. Mogensen, and M. Tonkonogi
Repeated static contractions increase mitochondrial vulnerability toward oxidative stress in human skeletal muscle
J Appl Physiol, September 1, 2006; 101(3): 833 - 839.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S.-J. Zhang, J. D. Bruton, A. Katz, and H. Westerblad
Limited oxygen diffusion accelerates fatigue development in mouse skeletal muscle
J. Physiol., April 15, 2006; 572(2): 551 - 559.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. D. Lamb, D. G. Stephenson, J. Bangsbo, and C. Juel
Point:Counterpoint: Lactic acid accumulation is an advantage/disadvantage during muscle activity
J Appl Physiol, April 1, 2006; 100(4): 1410 - 1412.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
T. L Dutka and G. D Lamb
Effect of low cytoplasmic [ATP] on excitation-contraction coupling in fast-twitch muscle fibres of the rat
J. Physiol., October 15, 2004; 560(2): 451 - 468.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
F. Abbate, J. D. Bruton, A. De Haan, and H. Westerblad
Prolonged force increase following a high-frequency burst is not due to a sustained elevation of [Ca2+]i
Am J Physiol Cell Physiol, July 1, 2002; 283(1): C42 - C47.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
H. Westerblad, D. G. Allen, and J. Lannergren
Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause?
Physiology, February 1, 2002; 17(1): 17 - 21.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
O. B Nielsen, F. de Paoli, and K. Overgaard
Protective effects of lactic acid on force production in rat skeletal muscle
J. Physiol., October 1, 2001; 536(1): 161 - 166.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. J Dahlstedt and H. Westerblad
Inhibition of creatine kinase reduces the rate of fatigue-induced decrease in tetanic [Ca2+]i in mouse skeletal muscle
J. Physiol., June 15, 2001; 533(3): 639 - 649.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. Lannergren, J. D Bruton, and H. Westerblad
Vacuole formation in fatigued skeletal muscle fibres from frog and mouse: effects of extracellular lactate
J. Physiol., August 1, 2000; 526(3): 597 - 611.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. J. DAHLSTEDT, A. KATZ, B. WIERINGA, and H. WESTERBLAD
Is creatine kinase responsible for fatigue? Studies of isolated skeletal muscle deficient in creatine kinase
FASEB J, May 1, 2000; 14(7): 982 - 990.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. L. Dutka and G. D. Lamb
Effect of lactate on depolarization-induced Ca2+ release in mechanically skinned skeletal muscle fibers
Am J Physiol Cell Physiol, March 1, 2000; 278(3): C517 - C525.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online