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J Appl Physiol 85: 432-436, 1998;
8750-7587/98 $5.00
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Vol. 85, Issue 2, 432-436, August 1998

Effect of aerosolized acetylcholine on bronchial blood flow

Nirmal B. Charan1,3, Paula Carvalho1,3, Shane R. Johnson1, William H. Thompson1,3, and S. Lakshminarayan2,3

1 Pulmonary Research Laboratory, Veterans Affairs Medical Center, Boise, Idaho 83702; 2 Veterans Affairs Medical Center, Seattle 98108; and 3 Division of Pulmonary/Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington 98195

We studied the effects of aerosolized as well as intravenous infusion of acetylcholine on bronchial blood flow in six anesthetized sheep. Intravenous infusion of acetylcholine, at a dose of 2 µg/kg, increased bronchial blood flow from 45 ± 15 (SE) to 74 ± 30 ml/min, and vascular conductance increased by 76 ± 22%. In contrast, aerosolized acetylcholine at doses of 2 and 20 µg/kg decreased bronchial vascular conductance by ~10%. At an aerosolized dose of 200 µg/kg, the bronchial vascular conductance increased by ~15%, and there was no further increase in conductance when the aerosolized dose was increased to 2,000 µg/kg. Pretreatment of animals with a nitric oxide synthase inhibitor, Nomega -nitro-L-arginine methyl ester hydrochloride, partially blocked the vasodilatory effects of intravenous acetylcholine and completely blocked the vasodilatory effects of high-dose aerosolized acetylcholine. These data suggest that aerosolized acetylcholine does not readily penetrate the vascular wall of bronchial circulatory system and, therefore, has minimal vasodilatory effects on the bronchial vasculature.

bronchial circulation; airway circulation; nitric oxide


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