Journal of Applied Physiology
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J Appl Physiol 85: 405-410, 1998;
8750-7587/98 $5.00
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Vol. 85, Issue 2, 405-410, August 1998

Low nitric oxide concentrations in exhaled gas and nasal airways of mammals without paranasal sinuses

Klaus Lewandowski1, Thilo Busch1, Hansjörg Lohbrunner1, Susanne Rensing2, Uwe Keske3, Herwig Gerlach1, and Konrad J. Falke1

1 Klinik für Anästhesiologie und operative Intensivmedizin, D-13353 Berlin; 2 Deutsches Primatenzentrum, D-37077 Göttingen; and 3 Strahlenklinik und Poliklinik, Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin, Campus Virchow-Klinikum, D-13353 Berlin, Germany

To investigate whether relevant levels of nasal nitric oxide (NO) are produced in the absence of paranasal sinuses, we studied 17 healthy baboons, mammals without any paranasal sinuses. The animals were anesthetized with ketamine hydrochloride and breathed spontaneously. While the baboons breathed through a face mask (mouths closed) connected to a respirator, NO concentrations in exhaled gas were sampled from the expiratory limb and analyzed by chemiluminescence. While the animals were breathing ambient air, nasal gas was sampled via a thin plastic tube and analyzed for NO concentrations by chemiluminescence. Mean NO concentration in the exhaled gas was 1.00 ± 0.59 parts/billion, and NO release was 4.28 ± 2.72 nl/min. A NO concentration of 4.79 ± 2.08 parts/billion was found in the nasal gas (NO release: 7.18 ± 3.13 nl/min). An age-dependent increase in nasal NO levels was not observed. Exhaled and nasal NO concentrations in baboons were markedly lower than in mammals with paranasal sinuses, suggesting that paranasal sinuses might be an anatomic requirement for production of relevant nasal NO levels.

baboons; anatomy; autoinhalation


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