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John B. Pierce Laboratory and Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06519
The ability of laser Doppler scanning to reproduce the spatial
pattern of cutaneous vascular conductance (CVC) in a
6.25-cm2 area of skin was
evaluated at supine rest (28°C), during thermal stress (cold and
heat), and during baroreceptor unloading with
40-mmHg lower body
negative pressure (LBNP). The spatial pattern of resting CVC was
similar on 3 different days, varying by 6 ± 3%. During cold
stress, 89 ± 2% of the skin area showed a decrease in skin blood
flow (37 ± 2%), whereas heat stress increased CVC in 94 ± 5%
of the skin area. During LBNP, the pattern of CVC response was not
uniform, and frequency analysis indicated that 47 ± 5% of the
pixels showed a reduction in CVC (>1 SE), 28 ± 2% of the skin
area were unaffected, and the remaining 26 ± 5% of the pixels showed some increase in CVC. These data indicate the ability of topographical perfusion mapping to provide quantitative and
reproducible information about the spatial distribution of CVC. In
addition, the site-to-site variability in reflex control of skin blood
flow during LBNP is intriguing and requires more rigorous evaluation.
laser Doppler; thermoregulation; baroreceptor
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