Journal of Applied Physiology
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J Appl Physiol 85: 286-293, 1998;
8750-7587/98 $5.00
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Vol. 85, Issue 1, 286-293, July 1998

Hysteresis of the nasal pressure-flow relationship during hyperpnea in normal subjects

Yong-Xin Shi1, Margaret Seto-Poon2, and John R. Wheatley1

1 Department of Respiratory Medicine, University of Sydney, Westmead Hospital, Westmead, New South Wales 2145; and 2 Department of Biological Sciences, University of Western Sydney, Nepean, New South Wales 2747, Australia

Hysteresis of the nasal airway pressure-flow relationship (PFR) is seen during hyperpnea, with lower nasal resistance during increasing inspiratory flow than during decreasing flow. We hypothesized that the nasal PFR hysteresis arose in the nasal vestibule airway because of progressive collapse during the inspiration. We measured the inspiratory transnasal and transvestibular PFR for one nasal passage in five normal subjects breathing via a nasal mask during voluntary hyperventilation, both with voluntary nostril flaring and without flaring. The inspiratory hysteresis (IH) was quantified as the ratio of the areas under the descending and ascending pressure-flow curves. Flaring reduced the vestibular IH from 1.96 ± 0.06 to 1.15 ± 0.06 and the nasal IH from 2.05 ± 0.13 to 1.28 ± 0.06 (both P < 0.01). Our results demonstrate that hysteresis arises in the compliant vestibule segment of the nasal airway, likely because of progressive collapse of the nasal vestibule during inspiration. The findings suggest that hysteresis is prevented by voluntary nostril flaring maintained throughout inspiration.

upper airway; pressure-flow hysteresis; alae nasi electromyogram; nasal airway mechanics; nasal vestibule; and nasal resistance


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