| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Physiological Sciences, University of Florida, Gainesville, Florida 32610; 2 Radiobiology Division, University of Utah, Salt Lake City, Utah 84112; and 3 Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, California 94121
As part of an experiment to study the role of corticosteroids in bone changes during spaceflight, male Sprague-Dawley rats (6 wk old, 165 g body weight) were placed in orbit for 17 days, in groups of six, in animal-enclosure modules (AEMs) aboard the space shuttle Columbia (STS-78). Control rats were group housed in a similar manner in ground-based AEMs or standard vivarium cages. Adrenal hypertrophy occurred in flight rats, but bone histomorphometric analyses revealed a lack of significant changes in bone mass and bone formation in these animals. Cancellous bone volume and osteoblast surface in the proximal tibial metaphysis were nearly the same in flight and ground-based rats. Normal levels of cancellous bone mass and bone formation were also detected in the lumbar vertebrae and femoral necks of flight rats. In the tibial diaphysis, periosteal bone formation rate was found to be identical in flight and ground-based rats. The results indicate that, under conditions of group housing in AEMs, spaceflight has minimal effects on bone mass and bone formation in rapidly growing rats. These findings emphasize the need to investigate the importance of rat age, strain, and especially housing conditions for studies of the skeletal effects of spaceflight.
weightlessness; bone histomorphometry; rat housing
This article has been cited by other articles:
|
|
 |
|
  M. J. Pecaut, G. M. Miller, G. A. Nelson, and D. S. Gridley Hypergravity-induced immunomodulation in a rodent model: hematological and lymphocyte function analyses J Appl Physiol, July 1, 2004; 97(1): 29 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Harrison, D. L. Allen, B. Girten, L. S. Stodieck, P. J. Kostenuik, T. A. Bateman, S. Morony, D. Lacey, and L. A. Leinwand Skeletal muscle adaptations to microgravity exposure in the mouse J Appl Physiol, December 1, 2003; 95(6): 2462 - 2470. [Abstract] [Full Text]
|
|
|
|
|
|
P. Dalton, M. Gould, B. Girten, L. S. Stodieck, and T. A. Bateman Preventing annoyance from odors in spaceflight: a method for evaluating the sensory impact of rodent housing J Appl Physiol, November 1, 2003; 95(5): 2113 - 2121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Pecaut, G. A. Nelson, L. L. Peters, P. J. Kostenuik, T. A. Bateman, S. Morony, L. S. Stodieck, D. L. Lacey, S. J. Simske, and D. S. Gridley Genetic Models in Applied Physiology: Selected Contribution: Effects of spaceflight on immunity in the C57BL/6 mouse. I. Immune population distributions J Appl Physiol, May 1, 2003; 94(5): 2085 - 2094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Gridley, G. A. Nelson, L. L. Peters, P. J. Kostenuik, T. A. Bateman, S. Morony, L. S. Stodieck, D. L. Lacey, S. J. Simske, and M. J. Pecaut Genetic Models in Applied Physiology: Selected Contribution: Effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets J Appl Physiol, May 1, 2003; 94(5): 2095 - 2103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Allen and S. A. Bloomfield Hindlimb unloading has a greater effect on cortical compared with cancellous bone in mature female rats J Appl Physiol, February 1, 2003; 94(2): 642 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Hatton, Q. Yue, J. Dierickx, C. Roullet, K. Otsuka, M. Watanabe, S. Coste, J. B. Roullet, T. Phanouvang, E. Orwoll, et al. Calcium metabolism and cardiovascular function after spaceflight J Appl Physiol, January 1, 2002; 92(1): 3 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Pecaut, S. J. Simske, and M. Fleshner Spaceflight induces changes in splenocyte subpopulations: effectiveness of ground-based models Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2072 - R2078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Turner Physiology of a Microgravity Environment: Invited Review: What do we know about the effects of spaceflight on bone? J Appl Physiol, August 1, 2000; 89(2): 840 - 847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Morey-Holton, B. P. Halloran, L. P. Garetto, and S. B. Doty Animal housing influences the response of bone to spaceflight in juvenile rats J Appl Physiol, April 1, 2000; 88(4): 1303 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Chapes, S. J. Simske, G. Sonnenfeld, E. S. Miller, and R. J. Zimmerman Effects of spaceflight and PEG-IL-2 on rat physiological and immunological responses J Appl Physiol, June 1, 1999; 86(6): 2065 - 2076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. CARMELIET and R. BOUILLON The effect of microgravity on morphology and gene expression of osteoblasts in vitro FASEB J, May 1, 1999; 13(9001): 129 - 134. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
