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Departments of Anatomy and Physiology and of Kinesiology, Kansas State University, Manhattan, Kansas 66506
Skeletal muscle oxidative enzyme capacity is impaired in
patients suffering from emphysema and chronic obstructive pulmonary disease. This effect may result as a consequence of the physiological derangements because of the emphysema condition or, alternatively, as a
consequence of the reduced physical activity level in these patients.
To explore this issue, citrate synthase (CS) activity was measured in
selected hindlimb muscles and the diaphragm of Syrian Golden hamsters 6 mo after intratracheal instillation of either saline (Con,
n = 7) or elastase [emphysema
(Emp); 25 units/100 g body weight, n = 8]. Activity level was monitored, and no difference between
groups was found. Excised lung volume increased with emphysema (Con,
1.5 ± 0.3 g; Emp, 3.0 ± 0.3 g,
P < 0.002). Emphysema significantly reduced CS activity in the gastrocnemius (Con, 45.1 ± 2.0; Emp, 39.2 ± 0.8 µmol · min
1 · g
wet wt1,
P < 0.05) and vastus lateralis (Con,
48.5 ± 1.5; Emp, 44.9 ± 0.8 µmol · min1 · g
wet wt1,
P < 0.05) but not in the plantaris
(Con, 47.4 ± 3.9; Emp, 48.0 ± 2.1 µmol · min1 · g
wet wt1,
P < 0.05) muscle. In contrast, CS
activity increased in the costal (Con, 61.1 ± 1.8; Emp, 65.1 ± 1.5 µmol · min1 · g
wet wt1,
P < 0.05) and crural (Con, 58.5 ± 2.0; Emp, 65.7 ± 2.2 µmol · min1 · g
wet wt1, P < 0.05) regions of the diaphragm. These data indicate that emphysema per
se can induce decrements in the oxidative capacity of certain
nonventilatory skeletal muscles that may contribute to exercise
limitations in the emphysematous patient.
chronic obstructive pulmonary disease; citrate synthase; diaphragm; exercise capacity
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