Journal of Applied Physiology AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 85: 133-138, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Host, H. H.
Right arrow Articles by Holloszy, J. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Host, H. H.
Right arrow Articles by Holloszy, J. O.
Vol. 85, Issue 1, 133-138, July 1998

Glycogen supercompensation masks the effect of a traininginduced increase in GLUT-4 on muscle glucose transport

Helen H. Host, Polly A. Hansen, Lorraine A. Nolte, May M. Chen, and John O. Holloszy

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110

Endurance exercise training induces a rapid increase in the GLUT-4 isoform of the glucose transporter in muscle. In fasted rats, insulin-stimulated muscle glucose transport is increased in proportion to the increase in GLUT-4. There is evidence that high muscle glycogen may decrease insulin-stimulated glucose transport. This study was undertaken to determine whether glycogen supercompensation interferes with the increase in glucose transport associated with an exercise-induced increase in GLUT-4. Rats were trained by means of swimming for 6 h/day for 2 days. Rats fasted overnight after the last exercise bout had an approximately twofold increase in epitrochlearis muscle GLUT-4 and an associated approximately twofold increase in maximally insulin-stimulated glucose transport activity. Epitrochlearis muscles of rats fed rodent chow after exercise were glycogen supercompensated (86.4 ± 4.8 µmol/g wet wt) and showed no significant increase in maximally insulin-stimulated glucose transport above the sedentary control value despite an approximately twofold increase in GLUT-4. Fasting resulted in higher basal muscle glucose transport rates in both sedentary and trained rats but did not significantly increase maximally insulin-stimulated transport in the sedentary group. We conclude that carbohydrate feeding that results in muscle glycogen supercompensation prevents the increase in maximally insulin-stimulated glucose transport associated with an exercise training-induced increase in muscle GLUT-4.

exercise; fasting; glucose transporters; insulin


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. C. Greenberg, M. J. Jurczak, A. M. Danos, and M. J. Brady
Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways
Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E1 - E8.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. E. Black, E. Mitchell, P. S. Freedson, S. R. Chipkin, and B. Braun
Improved insulin action following short-term exercise training: role of energy and carbohydrate balance
J Appl Physiol, December 1, 2005; 99(6): 2285 - 2293.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. O. Holloszy
Exercise-induced increase in muscle insulin sensitivity
J Appl Physiol, July 1, 2005; 99(1): 338 - 343.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. S Kump and F. W Booth
Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise
J. Physiol., February 1, 2005; 562(3): 829 - 838.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D.-H. Han, M. M. Chen, and J. O. Holloszy
Glucosamine and glucose induce insulin resistance by different mechanisms in rat skeletal muscle
Am J Physiol Endocrinol Metab, December 1, 2003; 285(6): E1267 - E1272.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. M. Garcia-Roves, D.-H. Han, Z. Song, T. E. Jones, K. A. Hucker, and J. O. Holloszy
Prevention of glycogen supercompensation prolongs the increase in muscle GLUT4 after exercise
Am J Physiol Endocrinol Metab, October 1, 2003; 285(4): E729 - E736.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. O. Holloszy
A forty-year memoir of research on the regulation of glucose transport into muscle
Am J Physiol Endocrinol Metab, March 1, 2003; 284(3): E453 - E467.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. L. Dumke, J. S. Rhodes, T. Garland Jr, E. Maslowski, J. G. Swallow, A. C. Wetter, and G. D. Cartee
Genetic selection of mice for high voluntary wheel running: effect on skeletal muscle glucose uptake
J Appl Physiol, September 1, 2001; 91(3): 1289 - 1297.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Terada, T. Yokozeki, K. Kawanaka, K. Ogawa, M. Higuchi, O. Ezaki, and I. Tabata
Effects of high-intensity swimming training on GLUT-4 and glucose transport activity in rat skeletal muscle
J Appl Physiol, June 1, 2001; 90(6): 2019 - 2024.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Kawanaka, L. A. Nolte, D.-H. Han, P. A. Hansen, and J. O. Holloszy
Mechanisms underlying impaired GLUT-4 translocation in glycogen-supercompensated muscles of exercised rats
Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1311 - E1318.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. W. Winder, B. F. Holmes, D. S. Rubink, E. B. Jensen, M. Chen, and J. O. Holloszy
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
J Appl Physiol, June 1, 2000; 88(6): 2219 - 2226.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. V. Chibalin, M. Yu, J. W. Ryder, X. M. Song, D. Galuska, A. Krook, H. Wallberg-Henriksson, and J. R. Zierath
Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin-receptor substrates 1 and 2
PNAS, January 4, 2000; 97(1): 38 - 43.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. Derave, S. Lund, G. D. Holman, J. Wojtaszewski, O. Pedersen, and E. A. Richter
Contraction-stimulated muscle glucose transport and GLUT-4 surface content are dependent on glycogen content
Am J Physiol Endocrinol Metab, December 1, 1999; 277(6): E1103 - E1110.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. F. Holmes, E. J. Kurth-Kraczek, and W. W. Winder
Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle
J Appl Physiol, November 1, 1999; 87(5): 1990 - 1995.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. S. Greiwe, R. C. Hickner, P. A. Hansen, S. B. Racette, M. M. Chen, and J. O. Holloszy
Effects of endurance exercise training on muscle glycogen accumulation in humans
J Appl Physiol, July 1, 1999; 87(1): 222 - 226.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Kawanaka, D.-H. Han, L. A. Nolte, P. A. Hansen, A. Nakatani, and J. O. Holloszy
Decreased insulin-stimulated GLUT-4 translocation in glycogen-supercompensated muscles of exercised rats
Am J Physiol Endocrinol Metab, May 1, 1999; 276(5): E907 - E912.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online