Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 84: 2010-2019, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mann, C. M.
Right arrow Articles by Hlastala, M. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mann, C. M.
Right arrow Articles by Hlastala, M. P.
Vol. 84, Issue 6, 2010-2019, June 1998

Redistribution of pulmonary blood flow during unilateral hypoxia in prone and supine dogs

Christopher M. Mann1, Karen B. Domino1, Sten M. Walther1,2, Robb W. Glenny2,3, Nayak L. Polissar4, and Michael P. Hlastala2,3

Departments of 1 Anesthesiology, 2 Medicine, and 3 Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195; and 4 The Mountain-Whisper-Light Statistical Consulting, Seattle, Washington 98112

We used fluorescent-labeled microspheres in pentobarbital-anesthetized dogs to study the effects of unilateral alveolar hypoxia on the pulmonary blood flow distribution. The left lung was ventilated with inspired O2 fraction of 1.0, 0.09, or 0.03 in random order; the right lung was ventilated with inspired O2 fraction of 1.0. The lungs were removed, cleared of blood, dried at total lung capacity, then cubed to obtain ~1,500 small pieces of lung (~1.7 cm3). The coefficient of variation of flow increased (P < 0.001) in the hypoxic lung but was unchanged in the hyperoxic lung. Most (70-80%) variance in flow in the hyperoxic lung was attributable to structure, in contrast to only 30-40% of the variance in flow in the hypoxic lung (P < 0.001). When adjusted for the change in total flow to each lung, 90-95% of the variance in the hyperoxic lung was attributable to structure compared with 70-80% in the hypoxic lung (P < 0.001). The hilar-to-peripheral gradient, adjusted for change in total flow, decreased in the hypoxic lung (P = 0.005) but did not change in the hyperoxic lung. We conclude that hypoxic vasoconstriction alters the regional distribution of flow in the hypoxic, but not in the hyperoxic, lung.

regional pulmonary blood flow; heterogeneity; gravitational gradient; hypoxic pulmonary vasoconstriction; fluorescence; microspheres


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
T. J. Arai, A. C. Henderson, D. J. Dubowitz, D. L. Levin, P. J. Friedman, R. B. Buxton, G. K. Prisk, and S. R. Hopkins
Hypoxic pulmonary vasoconstriction does not contribute to pulmonary blood flow heterogeneity in normoxia in normal supine humans
J Appl Physiol, April 1, 2009; 106(4): 1057 - 1064.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
Y. Yatsu, T. Tsubo, H. Ishihara, H. Nakamura, and K. Hirota
A New Method to Estimate Regional Pulmonary Blood Flow Using Transesophageal Echocardiography
Anesth. Analg., February 1, 2008; 106(2): 530 - 534.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. K. A. Lundblad, J. Thompson-Figueroa, G. B. Allen, L. Rinaldi, R. J. Norton, C. G. Irvin, and J. H. T. Bates
Airway Hyperresponsiveness in Allergically Inflamed Mice: The Role of Airway Closure
Am. J. Respir. Crit. Care Med., April 15, 2007; 175(8): 768 - 774.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
H. J. Lee, J.-G. Im, J. M. Goo, Y. I. Kim, M. W. Lee, H.-G. Ryu, J.-H. Bahk, and C.-G. Yoo
Acute Lung Injury: Effects of Prone Positioning on Cephalocaudal Distribution of Lung Inflation--CT Assessment in Dogs
Radiology, January 1, 2005; 234(1): 151 - 161.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
E. R. Swenson, M. Maggiorini, S. Mongovin, J. S. R. Gibbs, I. Greve, H. Mairbaurl, and P. Bartsch
Pathogenesis of High-Altitude Pulmonary Edema: Inflammation Is Not an Etiologic Factor
JAMA, May 1, 2002; 287(17): 2228 - 2235.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Chang, S. J. Lai-Fook, K. B. Domino, C. Schimmel, J. Hildebrandt, H. T. Robertson, R. W. Glenny, and M. P. Hlastala
Spatial distribution of ventilation and perfusion in anesthetized dogs in lateral postures
J Appl Physiol, February 1, 2002; 92(2): 745 - 762.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Slama, M. Gesch, J. C. Bock, S. M. Pietschmann, W. Schaffartzik, and U. Pison
Unilateral lung edema: effects on pulmonary gas exchange, hemodynamics, and pulmonary perfusion distribution
J Appl Physiol, October 1, 2000; 89(4): 1513 - 1521.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online