Journal of Applied Physiology
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J Appl Physiol 84: 2010-2019, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 6, 2010-2019, June 1998

Redistribution of pulmonary blood flow during unilateral hypoxia in prone and supine dogs

Christopher M. Mann1, Karen B. Domino1, Sten M. Walther1,2, Robb W. Glenny2,3, Nayak L. Polissar4, and Michael P. Hlastala2,3

Departments of 1 Anesthesiology, 2 Medicine, and 3 Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195; and 4 The Mountain-Whisper-Light Statistical Consulting, Seattle, Washington 98112

We used fluorescent-labeled microspheres in pentobarbital-anesthetized dogs to study the effects of unilateral alveolar hypoxia on the pulmonary blood flow distribution. The left lung was ventilated with inspired O2 fraction of 1.0, 0.09, or 0.03 in random order; the right lung was ventilated with inspired O2 fraction of 1.0. The lungs were removed, cleared of blood, dried at total lung capacity, then cubed to obtain ~1,500 small pieces of lung (~1.7 cm3). The coefficient of variation of flow increased (P < 0.001) in the hypoxic lung but was unchanged in the hyperoxic lung. Most (70-80%) variance in flow in the hyperoxic lung was attributable to structure, in contrast to only 30-40% of the variance in flow in the hypoxic lung (P < 0.001). When adjusted for the change in total flow to each lung, 90-95% of the variance in the hyperoxic lung was attributable to structure compared with 70-80% in the hypoxic lung (P < 0.001). The hilar-to-peripheral gradient, adjusted for change in total flow, decreased in the hypoxic lung (P = 0.005) but did not change in the hyperoxic lung. We conclude that hypoxic vasoconstriction alters the regional distribution of flow in the hypoxic, but not in the hyperoxic, lung.

regional pulmonary blood flow; heterogeneity; gravitational gradient; hypoxic pulmonary vasoconstriction; fluorescence; microspheres


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