| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen's University, Kingston, Ontario, Canada K7L 2V7
We compared
qualitative and quantitative aspects of perceived exertional dyspnea in
patients with interstitial lung disease (ILD) and normal subjects and
sought a physiological rationale for their differences. Twelve patients
with ILD [forced vital capacity = 64 ± 4 (SE)
%predicted] and 12 age-matched normal subjects performed
symptom-limited incremental cycle exercise tests with measurements of
dyspnea intensity (Borg scale), ventilation, breathing pattern,
operational lung volumes, and esophageal pressures (Pes). Qualitative
descriptors of dyspnea were selected at exercise cessation. Both groups
described increased "work and/or effort" and
"heaviness" of breathing; only patients with ILD described
"unsatisfied inspiratory effort" (75%), "increased
inspiratory difficulty" (67%), and "rapid breathing" (58%)
(P < 0.05 patients with ILD vs.
normal subjects). Borg-O2 uptake
(
O2) and Borg-ventilation
slopes were significantly greater during exercise in patients with ILD
(P < 0.01). At peak exercise, when
dyspnea intensity and inspiratory effort (Pes-to-maximal inspiratory
pressure ratio) were similar, the distinct qualitative perceptions of
dyspnea in patients with ILD were attributed to differences in dynamic
ventilatory mechancis, i.e., reduced inspiratory capacity, heightened
Pes-to-tidal volume ratio, and tachypnea. Factors contributing to
dyspnea intensity in both groups were also different: the best
correlate of the Borg-O2
slope in patients with ILD was the resting tidal volume-to-inspiratory
capacity ratio (r = 0.58, P < 0.05) and in normal subjects was
the slope of Pes-to-maximal inspiratory pressure ratio over
O2
(r = 0.60, P < 0.05).
respiratory sensation; respiratory mechanics; exercise
This article has been cited by other articles:
|
|
 |
|
  J Smith, P Albert, E Bertella, J Lester, S Jack, and P Calverley Qualitative aspects of breathlessness in health and disease Thorax, August 1, 2009; 64(8): 713 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Marcora Perception of effort during exercise is independent of afferent feedback from skeletal muscles, heart, and lungs J Appl Physiol, June 1, 2009; 106(6): 2060 - 2062. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Williams, P. Cafarella, T. Olds, J. Petkov, and P. Frith The Language of Breathlessness Differentiates Between Patients With COPD and Age-Matched Adults Chest, September 1, 2008; 134(3): 489 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Banzett, S. H. Pedersen, R. M. Schwartzstein, and R. W. Lansing The Affective Dimension of Laboratory Dyspnea: Air Hunger Is More Unpleasant than Work/Effort Am. J. Respir. Crit. Care Med., June 15, 2008; 177(12): 1384 - 1390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Travers, D. J. Dudgeon, K. Amjadi, I. McBride, K. Dillon, P. Laveneziana, D. Ofir, K. A. Webb, and D. E. O'Donnell Mechanisms of exertional dyspnea in patients with cancer J Appl Physiol, January 1, 2008; 104(1): 57 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Palange, S. A. Ward, K-H. Carlsen, R. Casaburi, C. G. Gallagher, R. Gosselink, D. E. O'Donnell, L. Puente-Maestu, A. M. Schols, S. Singh, et al. Recommendations on the use of exercise testing in clinical practice Eur. Respir. J., January 1, 2007; 29(1): 185 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. O'Donnell, A. L. Hamilton, and K. A. Webb Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD J Appl Physiol, October 1, 2006; 101(4): 1025 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Scano, L. Stendardi, and M. Grazzini Understanding dyspnoea by its language Eur. Respir. J., February 1, 2005; 25(2): 380 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Fierro-Carrion, D. A. Mahler, J. Ward, and J. C. Baird Comparison of Continuous and Discrete Measurements of Dyspnea During Exercise in Patients With COPD and Normal Subjects Chest, January 1, 2004; 125(1): 77 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
ATS/ACCP Statement on Cardiopulmonary Exercise Testing Am. J. Respir. Crit. Care Med., January 15, 2003; 167(2): 211 - 277. [Full Text] [PDF]
|
|
|
|
|
|
T. E. Dolmage and R. S. Goldstein Repeatability of Inspiratory Capacity During Incremental Exercise in Patients With Severe COPD Chest, March 1, 2002; 121(3): 708 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lanini, G. Misuri, F. Gigliotti, I. Iandelli, A. Pizzi, I. Romagnoli, and G. Scano Perception of Dyspnea in Patients With Neuromuscular Disease Chest, August 1, 2001; 120(2): 402 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. HAYOT, M. RAMONATXO, S. MATECKI, J. MILIC-EMILI, and C. PREFAUT Noninvasive Assessment of Inspiratory Muscle Function during Exercise Am. J. Respir. Crit. Care Med., December 1, 2000; 162(6): 2201 - 2207. [Abstract] [Full Text]
|
|
|
|
|
|
D. E. O'Donnell, H. H. Hong, and K. A. Webb Respiratory sensation during chest wall restriction and dead space loading in exercising men J Appl Physiol, May 1, 2000; 88(5): 1859 - 1869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Mahler and A. Harver Do You Speak the Language of Dyspnea? Chest, April 1, 2000; 117(4): 928 - 929. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
