Journal of Applied Physiology
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J Appl Physiol 84: 1740-1748, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 5, 1740-1748, May 1998

Hypoproteinemia, strong-ion difference, and acid-base status in critically ill patients

Peter Wilkes

University of Ottawa Heart Institute, Ottawa Civic Hospital, Ottawa, Ontario, Canada K1Y 4E9

The present study was a prospective, nonrandomized, observational examination of the relationship among hypoproteinemia and electrolyte and acid-base status in a critical care population of patients. A total of 219 arterial blood samples reviewed from 91 patients was analyzed for arterial blood gas, electrolytes, lactate, and total protein. Plasma strong-ion difference ([SID]) was calculated from [Na+] + [K+] - [Cl-] - [La-]. Total protein concentration was used to derive the total concentration of weak acid ([A]tot). [A]tot encompassed a range of 18.7 to 9.0 meq/l, whereas [SID] varied from 48.1 to 26.6 meq/l and was directly correlated with [A]tot. The decline in [SID] was primarily attributable to an increase in [Cl-]. A direct correlation was also noted between PCO2 and [SID], but not between PCO2 and [A]tot. The decrease in [SID] and PCO2 was such that neither [H+] nor [HCO-3] changed significantly with [A]tot.

metabolic alkalosis; electrolytes; critical care


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