Journal of Applied Physiology Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 84: 1716-1722, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Adams, G. R.
Right arrow Articles by McCue, S. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adams, G. R.
Right arrow Articles by McCue, S. A.
Vol. 84, Issue 5, 1716-1722, May 1998

Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats

Gregory R. Adams and Samuel A. McCue

Department of Physiology and Biophysics, University of California, Irvine, California 92697

Insulin-like growth factor I (IGF-I) peptide levels have been shown to increase in overloaded skeletal muscles (G. R. Adams and F. Haddad. J. Appl. Physiol. 81: 2509-2516, 1996). In that study, the increase in IGF-I was found to precede measurable increases in muscle protein and was correlated with an increase in muscle DNA content. The present study was undertaken to test the hypothesis that direct IGF-I infusion would result in an increase in muscle DNA as well as in various measurements of muscle size. Either 0.9% saline or nonsystemic doses of IGF-I were infused directly into a non-weight-bearing muscle of rats, the tibialis anterior (TA), via a fenestrated catheter attached to a subcutaneous miniosmotic pump. Saline infusion had no effect on the mass, protein content, or DNA content of TA muscles. Local IGF-I infusion had no effect on body or heart weight. The absolute weight of the infused TA muscles was ~9% greater (P < 0.05) than that of the contralateral TA muscles. IGF-I infusion resulted in significant increases in the total protein and DNA content of TA muscles (P < 0.05). As a result of these coordinated changes, the DNA-to-protein ratio of the hypertrophied TA was similar to that of the contralateral muscles. These results suggest that IGF-I may be acting to directly stimulate processes such as protein synthesis and satellite cell proliferation, which result in skeletal muscle hypertrophy.

insulin-like growth factor I; growth factors; somatomedin; muscle DNA content; fibroblast growth factor-2


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. Miyazaki and K. A. Esser
Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals
J Appl Physiol, April 1, 2009; 106(4): 1367 - 1373.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. G. Coffey, H. Pilegaard, A. P. Garnham, B. J. O'Brien, and J. A. Hawley
Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
J Appl Physiol, April 1, 2009; 106(4): 1187 - 1197.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. W. Bodell, E. Kodesh, F. Haddad, F. P. Zaldivar, D. M. Cooper, and G. R. Adams
Skeletal muscle growth in young rats is inhibited by chronic exposure to IL-6 but preserved by concurrent voluntary endurance exercise
J Appl Physiol, February 1, 2009; 106(2): 443 - 453.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
W. Matheny, E. Merritt, S. V. Zannikos, R. P. Farrar, and M. L. Adamo
Serum IGF-I-Deficiency Does Not Prevent Compensatory Skeletal Muscle Hypertrophy in Resistance Exercise
Experimental Biology and Medicine, February 1, 2009; 234(2): 164 - 170.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Piestun, M. Harel, M. Barak, S. Yahav, and O. Halevy
Thermal manipulations in late-term chick embryos have immediate and longer term effects on myoblast proliferation and skeletal muscle hypertrophy
J Appl Physiol, January 1, 2009; 106(1): 233 - 240.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
Y Liu, M Heinichen, K Wirth, D Schmidtbleicher, and J M Steinacker
Response of growth and myogenic factors in human skeletal muscle to strength training
Br. J. Sports Med., December 1, 2008; 42(12): 989 - 993.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. W. Hammers, E. K. Merritt, W. Matheny, M. L. Adamo, T. J. Walters, J. S. Estep, and R. P. Farrar
Functional deficits and insulin-like growth factor-I gene expression following tourniquet-induced injury of skeletal muscle in young and old rats
J Appl Physiol, October 1, 2008; 105(4): 1274 - 1281.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. K. Petrella, J.-s. Kim, D. L. Mayhew, J. M. Cross, and M. M. Bamman
Potent myofiber hypertrophy during resistance training in humans is associated with satellite cell-mediated myonuclear addition: a cluster analysis
J Appl Physiol, June 1, 2008; 104(6): 1736 - 1742.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. E. Spangenburg, D. Le Roith, C. W. Ward, and S. C. Bodine
A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy
J. Physiol., January 1, 2008; 586(1): 283 - 291.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. S. Quinn, B. G. Anderson, and S. R. Plymate
Muscle-specific overexpression of the type 1 IGF receptor results in myoblast-independent muscle hypertrophy via PI3K, and not calcineurin, signaling
Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1538 - E1551.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. R. Adams, F. Haddad, P. W. Bodell, P. D. Tran, and K. M. Baldwin
Combined isometric, concentric, and eccentric resistance exercise prevents unloading-induced muscle atrophy in rats
J Appl Physiol, November 1, 2007; 103(5): 1644 - 1654.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
S. D. R. Harridge
Plasticity of human skeletal muscle: gene expression to in vivo function
Exp Physiol, September 1, 2007; 92(5): 783 - 797.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. M. Bamman, J. K. Petrella, J.-s. Kim, D. L. Mayhew, and J. M. Cross
Cluster analysis tests the importance of myogenic gene expression during myofiber hypertrophy in humans
J Appl Physiol, June 1, 2007; 102(6): 2232 - 2239.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. L. J. van der Velden, R. C. J. Langen, M. C. J. M. Kelders, J. Willems, E. F. M. Wouters, Y. M. W. Janssen-Heininger, and A. M. W. J. Schols
Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3beta
Am J Physiol Cell Physiol, May 1, 2007; 292(5): C1636 - C1644.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. M. Heinemeier, J. L. Olesen, P. Schjerling, F. Haddad, H. Langberg, K. M. Baldwin, and M. Kjaer
Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types
J Appl Physiol, February 1, 2007; 102(2): 573 - 581.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Garma, C. Kobayashi, F. Haddad, G. R. Adams, P. W. Bodell, and K. M. Baldwin
Similar acute molecular responses to equivalent volumes of isometric, lengthening, or shortening mode resistance exercise
J Appl Physiol, January 1, 2007; 102(1): 135 - 143.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
B. C. Anderson, S. P. Christiansen, S. Grandt, R. W. Grange, and L. K. McLoon
Increased Extraocular Muscle Strength with Direct Injection of Insulin-like Growth Factor-I.
Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2461 - 2467.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. R. Barton
Viral expression of insulin-like growth factor-I isoforms promotes different responses in skeletal muscle
J Appl Physiol, June 1, 2006; 100(6): 1778 - 1784.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad and G. R. Adams
Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy
J Appl Physiol, April 1, 2006; 100(4): 1188 - 1203.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. L. J. van der Velden, R. C. J. Langen, M. C. J. M. Kelders, E. F. M. Wouters, Y. M. W. Janssen-Heininger, and A. M. W. J. Schols
Inhibition of glycogen synthase kinase-3{beta} activity is sufficient to stimulate myogenic differentiation
Am J Physiol Cell Physiol, February 1, 2006; 290(2): C453 - C462.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. E. Sellman, K. C. DeRuisseau, J. L. Betters, V. A. Lira, Q. A. Soltow, J. T. Selsby, and D. S. Criswell
In vivo inhibition of nitric oxide synthase impairs upregulation of contractile protein mRNA in overloaded plantaris muscle
J Appl Physiol, January 1, 2006; 100(1): 258 - 265.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Troosters, R. Casaburi, R. Gosselink, and M. Decramer
Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 19 - 38.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
O. Schakman, H. Gilson, V. de Coninck, P. Lause, J. Verniers, X. Havaux, J. M. Ketelslegers, and J. P. Thissen
Insulin-Like Growth Factor-I Gene Transfer by Electroporation Prevents Skeletal Muscle Atrophy in Glucocorticoid-Treated Rats
Endocrinology, April 1, 2005; 146(4): 1789 - 1797.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad, F. Zaldivar, D. M. Cooper, and G. R. Adams
IL-6-induced skeletal muscle atrophy
J Appl Physiol, March 1, 2005; 98(3): 911 - 917.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y.-C. Huang, R. G. Dennis, L. Larkin, and K. Baar
Rapid formation of functional muscle in vitro using fibrin gels
J Appl Physiol, February 1, 2005; 98(2): 706 - 713.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, A. D. Rogol, J. C. Lovejoy, M. Sheffield-Moore, N. Mauras, and C. Y. Bowers
Endocrine Control of Body Composition in Infancy, Childhood, and Puberty
Endocr. Rev., February 1, 2005; 26(1): 114 - 146.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad, K. M. Baldwin, and P. A. Tesch
Pretranslational markers of contractile protein expression in human skeletal muscle: effect of limb unloading plus resistance exercise
J Appl Physiol, January 1, 2005; 98(1): 46 - 52.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. J. Verheul, C. B. Mantilla, W.-Z. Zhan, M. Bernal, P. N. R. Dekhuijzen, and G. C. Sieck
Influence of corticosteroids on myonuclear domain size in the rat diaphragm muscle
J Appl Physiol, November 1, 2004; 97(5): 1715 - 1722.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. Chen and C. S. von Bartheld
Role of Exogenous and Endogenous Trophic Factors in the Regulation of Extraocular Muscle Strength during Development
Invest. Ophthalmol. Vis. Sci., October 1, 2004; 45(10): 3538 - 3545.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
V. Sartorelli and M. Fulco
Molecular and Cellular Determinants of Skeletal Muscle Atrophy and Hypertrophy
Sci. Signal., August 3, 2004; 2004(244): re11 - re11.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Lee, E. R. Barton, H. L. Sweeney, and R. P. Farrar
Viral expression of insulin-like growth factor-I enhances muscle hypertrophy in resistance-trained rats
J Appl Physiol, March 1, 2004; 96(3): 1097 - 1104.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Hameed, K. H. W. Lange, J. L. Andersen, P. Schjerling, M. Kjaer, S. D. R. Harridge, and G. Goldspink
The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men
J. Physiol., February 15, 2004; 555(1): 231 - 240.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad and G. R. Adams
Inhibition of MAP/ERK kinase prevents IGF-I-induced hypertrophy in rat muscles
J Appl Physiol, January 1, 2004; 96(1): 203 - 210.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. T. Morris, E. E. Spangenburg, and F. W. Booth
Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle
J Appl Physiol, January 1, 2004; 96(1): 398 - 404.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. B. P. CHARGE and M. A. RUDNICKI
Cellular and Molecular Regulation of Muscle Regeneration
Physiol Rev, January 1, 2004; 84(1): 209 - 238.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
S. P. Kirk, J. M. Oldham, F. Jeanplong, and J. J. Bass
Insulin-like Growth Factor-II Delays Early but Enhances Late Regeneration of Skeletal Muscle
J. Histochem. Cytochem., December 1, 2003; 51(12): 1611 - 1620.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
E. Barton and C. Morris
Review Article: Mechanisms and Strategies to Counter Muscle Atrophy
J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2003; 58(10): M923 - 926.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
L. K. McLoon and S. P. Christiansen
Increasing Extraocular Muscle Strength with Insulin-like Growth Factor II
Invest. Ophthalmol. Vis. Sci., September 1, 2003; 44(9): 3866 - 3872.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. E. Childs, E. E. Spangenburg, D. R. Vyas, and F. W. Booth
Temporal alterations in protein signaling cascades during recovery from muscle atrophy
Am J Physiol Cell Physiol, August 1, 2003; 285(2): C391 - C398.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Fournier, Z.-S. Huang, H. Li, X. Da, B. Cercek, and M. I. Lewis
Insulin-like growth factor I prevents corticosteroid-induced diaphragm muscle atrophy in emphysematous hamsters
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R34 - R43.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
O. Halevy, Y. Nadel, M. Barak, I. Rozenboim, and D. Sklan
Early Posthatch Feeding Stimulates Satellite Cell Proliferation and Skeletal Muscle Growth in Turkey Poults
J. Nutr., May 1, 2003; 133(5): 1376 - 1382.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M Hameed, R W Orrell, M Cobbold, G Goldspink, and S D R Harridge
Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise
J. Physiol., February 15, 2003; 547(1): 247 - 254.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
M. M. Bamman, V. J. Hill, G. R. Adams, F. Haddad, C. J. Wetzstein, B. A. Gower, A. Ahmed, and G. R. Hunter
Gender Differences in Resistance-Training-Induced Myofiber Hypertrophy Among Older Adults
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2003; 58(2): B108 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. E. Spangenburg, T. Abraha, T. E. Childs, J. S. Pattison, and F. W. Booth
Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent
Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E340 - E350.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. R. Adams
Exercise Effects on Muscle Insulin Signaling and Action: Invited Review: Autocrine/paracrine IGF-I and skeletal muscle adaptation
J Appl Physiol, September 1, 2002; 93(3): 1159 - 1167.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad and G. R. Adams
Exercise Effects on Muscle Insulin Signaling and Action: Selected Contribution: Acute cellular and molecular responses to resistance exercise
J Appl Physiol, July 1, 2002; 93(1): 394 - 403.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
V. Reynders, E. Marchand, G. Gayan-Ramirez, P. De Leyn, G. Verhoeven, and M. Decramer
Alterations in gene expression in hamster diaphragm after emphysema and lung volume reduction surgery
Eur. Respir. J., June 1, 2002; 19(6): 1064 - 1071.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
E. R. Barton, L. Morris, A. Musaro, N. Rosenthal, and H. L. Sweeney
Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice
J. Cell Biol., April 1, 2002; 157(1): 137 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. L. Awede, J.-P. Thissen, and J. Lebacq
Role of IGF-I and IGFBPs in the changes of mass and phenotype induced in rat soleus muscle by clenbuterol
Am J Physiol Endocrinol Metab, January 1, 2002; 282(1): E31 - E37.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. Halevy, A. Krispin, Y. Leshem, J. P. McMurtry, and S. Yahav
Early-age heat exposure affects skeletal muscle satellite cell proliferation and differentiation in chicks
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R302 - R309.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. J. Fedele, C. H. Lang, and P. A. Farrell
Immunization against IGF-I prevents increases in protein synthesis in diabetic rats after resistance exercise
Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E877 - E885.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. M. Bamman, J. R. Shipp, J. Jiang, B. A. Gower, G. R. Hunter, A. Goodman, C. L. McLafferty Jr., and R. J. Urban
Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans
Am J Physiol Endocrinol Metab, March 1, 2001; 280(3): E383 - E390.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. E. Dupont-Versteegden, R. J. L. Murphy, J. D. Houle, C. M. Gurley, and C. A. Peterson
Mechanisms leading to restoration of muscle size with exercise and transplantation after spinal cord injury
Am J Physiol Cell Physiol, December 1, 2000; 279(6): C1677 - C1684.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. V. Chakravarthy, B. S. Davis, and F. W. Booth
IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle
J Appl Physiol, October 1, 2000; 89(4): 1365 - 1379.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. R. Adams, F. Haddad, and K. M. Baldwin
Time course of changes in markers of myogenesis in overloaded rat skeletal muscles
J Appl Physiol, November 1, 1999; 87(5): 1705 - 1712.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. V. Chakravarthy, T. W. Abraha, R. J. Schwartz, M. L. Fiorotto, and F. W. Booth
Insulin-like Growth Factor-I Extends in Vitro Replicative Life Span of Skeletal Muscle Satellite Cells by Enhancing G1/S Cell Cycle Progression via the Activation of Phosphatidylinositol 3'-Kinase/Akt Signaling Pathway
J. Biol. Chem., November 10, 2000; 275(46): 35942 - 35952.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
E. R. Barton, L. Morris, A. Musaro, N. Rosenthal, and H. L. Sweeney
Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice
J. Cell Biol., April 1, 2002; 157(1): 137 - 148.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online