Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 84: 1687-1691, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hargreaves, M.
Right arrow Articles by Febbraio, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hargreaves, M.
Right arrow Articles by Febbraio, M. A.
Vol. 84, Issue 5, 1687-1691, May 1998

Muscle metabolites and performance during high-intensity, intermittent exercise

Mark Hargreaves1, Michael J. McKenna2, David G. Jenkins4, Stuart A. Warmington1, Jia L. Li2, Rodney J. Snow3, and Mark A. Febbraio1

1 Department of Physiology, The University of Melbourne, Parkville 3052; 2 Department of Human Movement, Recreation, and Performance, and 3 Exercise Metabolism Unit, Department of Chemistry and Biology, Centre for Rehabilitation, Exercise, and Sport Science, Victoria University of Technology, Footscray 3011; and 4 Department of Human Movement Studies, The University of Queensland, Brisbane 4072, Australia

Six men were studied during four 30-s "all-out" exercise bouts on an air-braked cycle ergometer. The first three exercise bouts were separated by 4 min of passive recovery; after the third bout, subjects rested for 4 min, exercised for 30 min at 30-35% peak O2 consumption, and rested for a further 60 min before completing the fourth exercise bout. Peak power and total work were reduced (P < 0.05) during bout 3 [765 ± 60 (SE) W; 15.8 ± 1.0 kJ] compared with bout 1 (1,168 ± 55 W, 23.8 ± 1.2 kJ), but no difference in exercise performance was observed between bouts 1 and 4 (1,094 ± 64 W, 23.2 ± 1.4 kJ). Before bout 3, muscle ATP, creatine phosphate (CP), glycogen, pH, and sarcoplasmic reticulum (SR) Ca2+ uptake were reduced, while muscle lactate and inosine 5'-monophosphate were increased. Muscle ATP and glycogen before bout 4 remained lower than values before bout 1 (P < 0.05), but there were no differences in muscle inosine 5'-monophosphate, lactate, pH, and SR Ca2+ uptake. Muscle CP levels before bout 4 had increased above resting levels. Consistent with the decline in muscle ATP were increases in hypoxanthine and inosine before bouts 3 and 4. The decline in exercise performance does not appear to be related to a reduction in muscle glycogen. Instead, it may be caused by reduced CP availability, increased H+ concentration, impairment in SR function, or some other fatigue-inducing agent.

muscle fatigue; metabolism; glycogen; creatine phosphate; hydrogen ion


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. J. Gibala, S. L. McGee, A. P. Garnham, K. F. Howlett, R. J. Snow, and M. Hargreaves
Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1{alpha} in human skeletal muscle
J Appl Physiol, March 1, 2009; 106(3): 929 - 934.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Amann and J. A. Dempsey
Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance
J. Physiol., January 1, 2008; 586(1): 161 - 173.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. A. Parker, S. L. Smithmyer, J. A. Pelberg, A. D. Mishkin, M. D. Herr, and D. N. Proctor
Sex differences in leg vasodilation during graded knee extensor exercise in young adults
J Appl Physiol, November 1, 2007; 103(5): 1583 - 1591.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Fischer, M. Esbjornsson, R. L. Sabina, A. Stromberg, M. Peyrard-Janvid, and B. Norman
AMP deaminase deficiency is associated with lower sprint cycling performance in healthy subjects
J Appl Physiol, July 1, 2007; 103(1): 315 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. J. Ellingson, D. G. Chesser, and W. W. Winder
Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25
Am J Physiol Endocrinol Metab, February 1, 2007; 292(2): E400 - E407.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
M S Kovacs and A J Pearce
Applied physiology of tennis performance * COMMENTARY.
Br. J. Sports Med., May 1, 2006; 40(5): 381 - 386.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Thomas, P. Sirvent, S. Perrey, E. Raynaud, and J. Mercier
Relationships between maximal muscle oxidative capacity and blood lactate removal after supramaximal exercise and fatigue indexes in humans
J Appl Physiol, December 1, 2004; 97(6): 2132 - 2138.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
A St Clair Gibson and T D Noakes
Evidence for complex system integration and dynamic neural regulation of skeletal muscle recruitment during exercise in humans
Br. J. Sports Med., December 1, 2004; 38(6): 797 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
A. Crisafulli, C. Carta, F. Melis, F. Tocco, F. Frongia, U. M Santoboni, P. Pagliaro, and A. Concu
Haemodynamic responses following intermittent supramaximal exercise in athletes
Exp Physiol, November 1, 2004; 89(6): 665 - 674.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Leppik, R. J. Aughey, I. Medved, I. Fairweather, M. F. Carey, and M. J. McKenna
Prolonged exercise to fatigue in humans impairs skeletal muscle Na+-K+-ATPase activity, sarcoplasmic reticulum Ca2+ release, and Ca2+ uptake
J Appl Physiol, October 1, 2004; 97(4): 1414 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. A. Duhamel, H. J. Green, S. D. Sandiford, J. G. Perco, and J. Ouyang
Effects of progressive exercise and hypoxia on human muscle sarcoplasmic reticulum function
J Appl Physiol, July 1, 2004; 97(1): 188 - 196.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Billaut, M. Giacomoni, and G. Falgairette
Maximal intermittent cycling exercise: effects of recovery duration and gender
J Appl Physiol, October 1, 2003; 95(4): 1632 - 1637.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. W. Russ and J. A. Kent-Braun
Sex differences in human skeletal muscle fatigue are eliminated under ischemic conditions
J Appl Physiol, June 1, 2003; 94(6): 2414 - 2422.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. A. Lacombe, K. W. Hinchcliff, R. J. Geor, and C. R. Baskin
Muscle glycogen depletion and subsequent replenishment affect anaerobic capacity of horses
J Appl Physiol, October 1, 2001; 91(4): 1782 - 1790.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Norman, R. L. Sabina, and E. Jansson
Regulation of skeletal muscle ATP catabolism by AMPD1 genotype during sprint exercise in asymptomatic subjects
J Appl Physiol, July 1, 2001; 91(1): 258 - 264.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. R. Harmer, M. J. McKenna, J. R. Sutton, R. J. Snow, P. A. Ruell, J. Booth, M. W. Thompson, N. A. Mackay, C. G. Stathis, R. M. Crameri, et al.
Skeletal muscle metabolic and ionic adaptations during intense exercise following sprint training in humans
J Appl Physiol, November 1, 2000; 89(5): 1793 - 1803.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. L. Parolin, A. Chesley, M. P. Matsos, L. L. Spriet, N. L. Jones, and G. J. F. Heigenhauser
Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise
Am J Physiol Endocrinol Metab, November 1, 1999; 277(5): E890 - E900.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online