Journal of Applied Physiology Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 84: 1633-1638, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bitterman, N.
Right arrow Articles by Bitterman, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bitterman, N.
Right arrow Articles by Bitterman, H.
Vol. 84, Issue 5, 1633-1638, May 1998

L-Arginine-NO pathway and CNS oxygen toxicity

Noemi Bitterman1,4 and Haim Bitterman2,3,4

1 Israel Naval Medical Institute, Medical Corps, Israeli Defense Forces, Haifa 31080; 2 Department of Internal Medicine A, Carmel Medical Center, 3 The Rappaport Family Institute for Research in the Medical Sciences, and 4 Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 34362, Israel

The involvement of the L-arginine-nitric oxide (NO) pathway in the pathogenesis of hyperoxia-induced seizures was studied by using agents controlling NO levels. We selected two inhibitors of nitric oxide synthase, the systemic inhibitor Nomega -nitro-L-arginine methyl ester (L-NAME) and the novel cerebral-specific inhibitor 7-nitroindazole, and two generators of NO, the NO donor S-nitroso-N-acetylpenicillamine and the physiological precursor L-arginine. Rats with chronic cortical electrodes were injected intraperitoneally with different doses of one of the agents or their vehicles before exposure to 0.5 MPa O2 and O2 with 5% CO2 at an absolute pressure of 0.5 MPa. The duration of the latent period until the onset of electrical discharges in the electroencephalogram was used as an index of central nervous system O2 toxicity. The two nitric oxide synthase inhibitors L-NAME and 7-nitroindazole significantly prolonged the latent period to the onset of seizures on exposure to both hyperbaric O2 and to the hypercapnic-hyperoxic mixture. Pretreatment with the NO donor S-nitroso-N-acetylpenicillamine significantly shortened the latent period, whereas L-arginine, the physiological precursor of NO, significantly prolonged the latent period to onset of seizures. Our results suggest that the L-arginine-NO pathway is involved in the pathophysiology of hyperoxia-induced seizures via various regulating mechanisms.

central nervous system; hyperoxia; Nomega -nitro-L-arginine methyl ester; hypercapnia; nitric oxide; arginine; nitric oxide donors; 7-nitroindazole; S-nitroso-N-acetylpenicillamine


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
I. T. Demchenko, A. Ruehle, B. W. Allen, R. D. Vann, and C. A. Piantadosi
Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen
J Appl Physiol, April 1, 2009; 106(4): 1234 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
I. T. Demchenko, K. E. Welty-Wolf, B. W. Allen, and C. A. Piantadosi
Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide
Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L229 - L238.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. B. Dean, D. K. Mulkey, A. J. Garcia III, R. W. Putnam, and R. A. Henderson III
Neuronal sensitivity to hyperoxia, hypercapnia, and inert gases at hyperbaric pressures
J Appl Physiol, September 1, 2003; 95(3): 883 - 909.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. T. Demchenko, A. E. Boso, T. J. O'Neill, P. B. Bennett, and C. A. Piantadosi
Nitric oxide and cerebral blood flow responses to hyperbaric oxygen
J Appl Physiol, April 1, 2000; 88(4): 1381 - 1389.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online