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J Appl Physiol 84: 1604-1609, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 5, 1604-1609, May 1998

Leukocyte adhesion molecule expression during intense resistance exercise

Mary P. Miles1, Sharyn K. Leach1, William J. Kraemer2, Keiichiro Dohi2, Jill A. Bush2, and Andrea M. Mastro1

1 Department of Biochemistry and Molecular Biology, and 2 Department of Kinesiology, Noll Laboratory, and Laboratory of Sports Medicine, Pennsylvania State University, University Park, Pennsylvania 16802

We hypothesized that expression of L-selectin and very late antigen-4 (VLA-4) integrin adhesion molecules would influence cell type-specific redistribution during exercise. Women subjects performed six sets of 10-repetition maximum squats. L-selectin and VLA-4 integrin were measured by using flow cytometry pre- and postexercise on peripheral blood neutrophils and lymphocytes (n = 29 subjects) and lymphocyte subsets (n = 70 subjects), respectively. Neutrophil concentration increased 41.8% (P < 0.001), whereas the percent expressing L-selectin was unchanged (79%). Lymphocyte concentration increased 61.8% (P < 0.001). The percent of T cells expressing L-selectin decreased from 73.5 ± 8.9 to 68.2 ± 11.4% (P < 0.001); the combined population of natural killer and B cells expressing L-selectin decreased from 80.4 ± 22.5 to 62.7 ± 25.8% (P < 0.001). VLA-4 integrin was expressed by nearly all lymphocytes both pre- and postexercise. The proportional decrease in L-selectin positive cells could have resulted from 1) shedding of L-selectin, 2) selective entry of L-selectin-negative subsets, or 3) selective removal of L-selectin-positive subsets.

very late antigen-4 integrin; L-selectin; neutrophils; lymphocytes; cortisol


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