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2-agonist
Divisions of 1 Clinical Immunology and 2 Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224
This study
was performed to determine the degree to which
2-adrenergic receptor agonists
can reverse the allergen-induced late reduction in lung
function. On two occasions, seven asthmatic subjects were
administered terbutaline or its vehicle by intravenous infusion 7 h
after inhaled allergen, at which point the forced expiratory volume in
1 s was 57% of baseline. On another occasion, terbutaline was infused
at baseline to determine maximal attainable bronchodilation. After
allergen challenge, terbutaline rapidly improved lung function. At the
end of terbutaline infusion, the forced expiratory volume in 1 s
reached 100 ± 1.3% of baseline and 84.2 ± 4.3% of maximal
attainable value, but the bronchodilating effect of the -agonist did
not plateau. The values for forced vital capacity were 102 ± 1.3%
of baseline and 95.1 ± 3% of maximal attainable
value. The kinetics of the terbutaline effect, when it was
infused at baseline, were similar to those in the late phase. Because
the late-phase reduction in lung function is rapidly reversible by
2-adrenergic agonists, we
conclude that it is caused mainly by bronchial smooth muscle spasm.
asthma; bronchospasm; bronchoprovocation; bronchodilator
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