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J Appl Physiol 84: 1470-1474, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 4, 1470-1474, April 1998

SPECIAL COMMUNICATION
Prolonged exposure to halothane and associated changes in carbohydrate metabolism in rat muscles in vivo

Luis D. M. C.-B. Ferreira, T. Norman Palmer, and Paul A. Fournier

Departments of Biochemistry and Human Movement, University of Western Australia, Nedlands, Western Australia 6907, Australia

Halothane, an anesthetic presently used in animal experimentation, is reported to stimulate glycogen breakdown in isolated preparations of rat skeletal muscles, suggesting that it may not be a suitable anesthetic for the study of glycogen metabolism in rats in vivo. The purpose of this study was to establish whether prolonged exposure to halothane in rats in vivo is associated with accelerated glycogenolysis. Exposure of rats to halothane for up to 1 h was not accompanied by either any change in the levels of glycogen or increase in activity ratios of glycogen phosphorylase in muscles, irrespective of their fiber compositions. In marked contrast, the levels of lactate, inorganic phosphate, glucose 1-phosphate, glucose 6-phosphate, fructose 1,6-bisphosphate, and fructose 2,6-bisphosphate changed progressively during anesthesia. Accordingly, the interpretation of muscle metabolite levels must be performed with caution in experiments involving prolonged exposure to halothane. Overall, our findings indicate that the reported halothane-mediated stimulation of glycogen breakdown in vitro is likely to be an artifact and that halothane is a suitable anesthetic for experiments concerned with glycogen metabolism in rats.

glycogen; glycolysis; malignant hyperthermia


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