Journal of Applied Physiology AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 84: 1316-1322, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tarczy-Hornoch, P.
Right arrow Articles by Jackson, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tarczy-Hornoch, P.
Right arrow Articles by Jackson, J. C.

Vol. 84, Issue 4, 1316-1322, April 1998

Surfactant replacement increases compliance in premature lamb lungs during partial liquid ventilation in situ

Peter Tarczy-Hornoch, Jack Hildebrandt, Thomas A. Standaert, and J. Craig Jackson

Departments of Pediatrics, Medicine, and Physiology/Biophysics, University of Washington, Seattle, Washington 98195

Treatments available to improve compliance in surfactant-deficient states include exogenous surfactant (ES) and either partial (PLV) or total liquid ventilation (TLV) with perfluorochemical (PFC). Because of the additional air-lung and air-PFC interfaces introduced during PLV compared with TLV, we hypothesized that compliance would be worse during PLV than during TLV. Because surfactant is able to reduce interfacial tension between air and lung as well as between PFC and lung, we further hypothesized that compliance would improve with surfactant treatment before PLV. In excised preterm lamb lungs, we used Survanta for surfactant replacement and perflubron as the PFC. Compliance during PLV was intermediate between TLV and gas inflation, both with and without surfactant. Surfactant improved compliance during PLV, compared with PLV alone. Because of the force-balance equation governing the behavior of immiscible droplets on liquid surfaces, we predict that PFC droplets spread during PLV to cover the alveolar surface in surfactant-deficient lungs during most of lung inflation and deflation but that the PFC would retract into droplets in surfactant-sufficient lungs, except at end inspiration.

lung mechanics; exogenous surfactant; perfluorochemical; alveolar spreading; lung interfaces


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
S. Wolf, H. Lohbrunner, T. Busch, A. Sterner-Kock, M. Deja, A. Sarrafzadeh, U. Neumann, and U. Kaisers
Small dose of exogenous surfactant combined with partial liquid ventilation in experimental acute lung injury: effects on gas exchange, haemodynamics, lung mechanics, and lung pathology
Br. J. Anaesth., October 1, 2001; 87(4): 593 - 601.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M.-J. Jeng, D. Trevisanuto, C. M. Weis, W. W. Fox, A. B. Cullen, M. R. Wolfson, and T. H. Shaffer
Role of ventilation strategy on perfluorochemical evaporation from the lungs
J Appl Physiol, April 1, 2001; 90(4): 1365 - 1372.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
T. Nakamura, S. Matsuzawa, M. Sugiura, and M. Tamura
A randomised control study of partial liquid ventilation after airway lavage with exogenous surfactant in a meconium aspiration syndrome animal model
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2000; 82(2): 160F - 162.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. P. KINSELLA, T. A. PARKER, H. GALAN, B. C. SHERIDAN, and S. H. ABMAN
Independent and Combined Effects of Inhaled Nitric Oxide, Liquid Perfluorochemical, and High-Frequency Oscillatory Ventilation in Premature Lambs with Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., April 1, 1999; 159(4): 1220 - 1227.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online