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J Appl Physiol 84: 1269-1277, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 4, 1269-1277, April 1998

HSP70 expression in the CNS in response to exercise and heat stress in rats

T. J. Walters1, K. L. Ryan2, M. R. Tehrany2, M. B. Jones2, L. A. Paulus3, and P. A. Mason1

1 Veridian, Inc. at Air Force Research Laboratory, Human Effectiveness Directorate, Directed Energy Bioeffects Division, Brooks Air Force Base; 2 Department of Biology, Trinity University, San Antonio 78212; and 3 Air Force Research Laboratory, Human Effectiveness Directorate, Directed Energy Bioeffects Division, Brooks Air Force Base, Texas 78235-5324

We have previously documented the regional distribution of 70-kDa heat shock protein (HSP70) in brains of rats made hyperthermic by brief exposure to high-powered microwaves (HPM; 2.06 GHz). We now compare HSP70 expression induced by HPM exposure to that induced by exertional and/or environmental heat stress. Rats were chronically implanted with a temperature probe guide in the hypothalamic region of the brain (Tbr). After recovery, the following treatment groups were examined: HPM; sham exposed; treadmill exercise at room temperature (24°C; Ex-1); treadmill exercise in a warm environment (34°C; Ex-2); and sedentary groups (Sed-1 and Sed-2), in which ambient temperature was adjusted so that the Tbr mimicked the Tbr in the corresponding exercise groups. Significant HSP70 expression occurred only in the hyperthermic (Ex-2, Sed-2, and HPM) groups. The pattern of HSP70 expression was similar among Ex-2 and Sed-2 rats but differed from that in HPM rats. We conclude that 1) the pattern of HSP70 expression differs between HPM and nonmicrowave heating, and 2) exercise alone was not sufficient to induce central HSP70 expression.

heat shock protein 70; central nervous system; brain; electromagnetic fields; microwaves; thermoregulation; treadmill


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