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Vol. 84, Issue 3, 995-1002, March 1998
O2 max
with right-shifted Hb-O2
dissociation curve at a constant
O2 delivery in dog muscle in
situ
If the diffusive component of
O2 transport in muscle is
important in determining exercise capacity, an increased
capillary-to-tissue PO2 difference
should enhance gas exchange from blood to skeletal muscle during
exercise. Thus a rightward shift in the
O2 dissociation curve should
theoretically increase O2
extraction and improve maximal O2
uptake (
O2 max). To
test this hypothesis, we used the canine gastrocnemius muscle to study
maximal exercise in eight dogs at a normal
P50 (33.1 ± 0.4 Torr) and with
the O2 dissociation curve shifted to the right by an
allosteric modifier of hemoglobin (Hb) (methylpropionic acid, RSR-13;
P50 = 53.2 ± 5.0 Torr). Four
control dogs were also studied before and after infusion of vehicle.
O2 (100%) was inspired during
exercise to maintain arterial saturation in both conditions. The muscle
was surgically isolated and electrically stimulated (tetanic train: 0.2-ms stimuli for 200-ms duration at 50 Hz, once per s). To
maintain O2 delivery (pre-RSR-13 = 19.1 ± 2.9; RSR-13 = 19.6 ± 2.5 ml · 100 g
1 · min1),
the muscle was pump perfused. At a constant
O2 delivery, RSR-13 significantly
increased percent O2 extraction
(pre-RSR-13 = 61 ± 4.0; RSR-13 = 75.5 ± 4.7) and
muscle O2 max
(pre-RSR-13 = 11.8 ± 2.1; RSR-13 = 14.2 ± 1.5 ml · 100 g1 · min1).
This improvement in
O2 max with increased
P50 demonstrates its
O2 supply dependence when
P50 is normal and the importance of O2 diffusive transport to
muscle at maximal exercise.
oxygen affinity; exercise; diffusion; partial pressure of oxygen at 50% hemoglobin saturation; skeletal muscle; oxyhemoglobin; maximal oxygen uptake
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