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Vol. 84, Issue 3, 980-986, March 1998
1 Departments of Anesthesiology
and Physiology and Biophysics, University of Texas Medical Branch and
Shriners Burns Institute, Galveston, Texas 77555-0833;
2 Department of Plastic and
Reconstructive Surgery,
We determined the effect of reduced bronchial
blood flow on lung fluid flux through changes in lung lymph flow, lung
wet weight-to-dry weight (wet/dry) ratios, and pulmonary microvascular
reflection coefficient (
). In the first of two surgical procedures,
Merino ewes (n = 21) were surgically
prepared for chronic study. Five to seven days later, in a second
operation, the bronchial artery of the injection group
(n = 7) was ligated, and 4 ml of 70%
ethanol were injected into the bronchial artery to cause sclerosis of the airway circulation. In the ligation group
(n = 7), only the bronchial artery was
ligated. In the sham group (n = 7),
the bronchial artery was surgically exposed but left intact without
ligation or ethanol injection. One day after these operations the
animals received a tracheotomy and 48 breaths of cotton smoke. The
value of was determined at two points: 24 h before the second
surgical procedure and 24 h after smoke inhalation. Lung lymph flow,
blood-gas parameters, and hemodynamic data were measured every 4 h
after injury. At the end of investigation, samples of lung were taken for determination of blood-free wet/dry ratio. In the sham group, inhalation injury induced a gradual increase in pulmonary vascular resistance and lung lymph flow, which was associated with deterioration of oxygenation. Reduction of the bronchial blood flow attenuated these
pathophysiological changes, and the degree of this attenuation was
greater in the injection group than in the ligation group. The value of
was significantly higher after smoke inhalation in the injection
group compared with the sham group (0.77 ± 0.04 vs. 0.61 ± 0.03, means ± SE) at 24 h. The mean wet/dry ratio value of the
injection group animals was 30% less than that of the sham group. Our
data show that the bronchial circulation contributes to edema formation
in the lung occurring after acute lung injury with smoke inhalation.
lung lymphatic; reflection coefficient; pulmonary edema; bronchial artery; acute lung injury; burns; pulmonary
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