Journal of Applied Physiology AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 84: 971-979, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sexton, W. L.
Right arrow Articles by Poole, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sexton, W. L.
Right arrow Articles by Poole, D. C.

Vol. 84, Issue 3, 971-979, March 1998

Effects of emphysema on diaphragm blood flow during exercise

William L. Sexton1 and David C. Poole2

1 Department of Physiology, Kirksville College of Osteopathic Medicine, Kirksville, Missouri 63501; and 2 Departments of Kinesiology and Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506-5602

Chronic hyperinflation of the lung in emphysema displaces the diaphragm caudally, thereby placing it in a mechanically disadvantageous position and contributing to the increased work of breathing. We tested the hypothesis that total and regional diaphragm blood flows are increased in emphysema, presumably reflecting an increased diaphragm energetic demand. Male Syrian Golden hamsters were randomly divided into emphysema (E; intratracheal elastase 25 units/100 g body wt) and control (C; saline) groups, and experiments were performed 16-20 wk later. The regional distribution of blood flow within the diaphragm was determined by using radiolabeled microspheres in hamsters at rest and during treadmill exercise (walking at 20 feet/min, 20% grade). Consistent with pronounced emphysema, lung volume per unit body weight was greater in E hamsters (C, 59.3 ± 1.8; E, 84.5 ± 5.0 ml/kg; P < 0.001) and arterial PO2 was lower both at rest (C, 74 ± 3; E, 59 ± 2 Torr; P < 0.001) and during exercise (C, 93 ± 3; E, 69 ± 4 Torr; P < 0.001). At rest, total diaphragm blood flow was not different between C and E hamsters (C, 47 ± 4; E, 38 ± 4 ml · min-1 · 100 g-1; P = 0.18). In both C and E hamsters, blood flow at rest was lower in the ventral costal region of the diaphragm than in the dorsal and medial costal regions and the crural diaphragm. During exercise in both C and E hamsters, blood flows increased more in the dorsal and medial costal regions and in the crural diaphragm than in the ventral costal region. Total diaphragm blood flow was greater in E hamsters during exercise (C, 58 ± 7; E, 90 ± 14 ml · min-1 · 100 g-1; P = 0.03), as a consequence of significantly higher blood flows in the medial and ventral costal regions and crural diaphragm. In addition, exercise-induced increases in intercostal (P < 0.005) and abdominal (P < 0.05) muscle blood flows were greater in E hamsters. The finding that diaphragm blood flow was greater in E hamsters during exercise supports the contention that emphysema increases the energetic requirements of the diaphragm.

regional blood flow; diaphragm energetics; radiolabeled microspheres

JAP 84(3):971-979
0161-7567/98 $5.00 Copyright © 1998 the American Physiological Society


This article has been cited by other articles:


Home page
 ThoraxHome page
A Borghi-Silva, C C Oliveira, C Carrascosa, J Maia, D C Berton, F Queiroga Jr, E M Ferreira, D R Almeida, L E Nery, and J A Neder
Respiratory muscle unloading improves leg muscle oxygenation during exercise in patients with COPD
Thorax, October 1, 2008; 63(10): 910 - 915.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Borzone, L. Liberona, P. Olmos, C. Saez, M. Meneses, T. Reyes, R. Moreno, and C. Lisboa
Rat and hamster species differences in susceptibility to elastase-induced pulmonary emphysema relate to differences in elastase inhibitory capacity
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1342 - R1349.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
J. P Mattson and J. C Martin
Emphysema-induced reductions in locomotory skeletal muscle contractile function
Exp Physiol, July 1, 2005; 90(4): 519 - 525.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J.P. Mattson, M.D. Delp, and D.C. Poole
Differential effects of emphysema on skeletal muscle fibre atrophy in hamsters
Eur. Respir. J., May 1, 2004; 23(5): 703 - 707.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. L. Johnson Jr., C. C. W. Hsia, S.-I. Takeda, J. L. Wait, and R. W. Glenny
Efficient design of the diaphragm: distribution of blood flow relative to mechanical advantage
J Appl Physiol, September 1, 2002; 93(3): 925 - 930.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. C. POOLE, C. A. KINDIG, and B. J. BEHNKE
Effects of Emphysema on Diaphragm Microvascular Oxygen Pressure
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1081 - 1086.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
C. C. W. Hsia, S.-I. Takeda, E. Y. Wu, R. W. Glenny, and R. L. Johnson Jr.
Adaptation of respiratory muscle perfusion during exercise to chronically elevated ventilatory work
J Appl Physiol, November 1, 2000; 89(5): 1725 - 1736.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. P. Mattson and D. C. Poole
Pulmonary emphysema decreases hamster skeletal muscle oxidative enzyme capacity
J Appl Physiol, July 1, 1998; 85(1): 210 - 214.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online