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Vol. 84, Issue 3, 1024-1029, March 1998
1 Departamento de Ciencias Fisiológicas, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima 100, Peru; and 2 University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom
High-altitude
(HA) natives have blunted ventilatory sensitivities to hypoxia, and it
is uncertain whether this blunting is reversible on migration to sea
level (SL). To study this, the ventilatory sensitivities to hypoxia of
HA natives residing near SL were compared with those of SL natives. Two
studies were performed. In study A, 24 HA subjects who had lived above 3,000 m for an average of 14 yr and had
been resident at SL for an average of 23 yr were compared with 23 SL
controls. In study B, 25 HA subjects who had lived above 3,500 m for at least 20 yr and had been resident at
SL for no more than 5 yr were compared with 25 SL controls. Hypoxic
sensitivities were assessed by breathing seven progressively more
hypoxic gas mixtures that contained progressively more
CO2 in an attempt to maintain
isocapnia throughout. The ventilatory sensitivities to hypoxia
(l · min
1 · %1 · m2)
did not differ significantly (by analysis of variance) between HA and
SL natives in either study A
(
0.51 ± 0.25, mean ± SD) or study
B (0.34 ± 0.15), but the ventilatory
sensitivities did differ significantly between the two studies for
reasons which are not entirely clear. We conclude that HA natives
residing at SL, even if previously at HA for >20 yr, do not maintain
the severely blunted hypoxic responses that have been reported in such
individuals.
chronic hypoxia; hypoxic blunting; hypoxic insensitivity; humans
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