Journal of Applied Physiology Journal of Applied Physiology
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J Appl Physiol 84: 709-716, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 2, 709-716, February 1998

MODELING IN PHYSIOLOGY
Parameter estimation and confidence intervals for Xe-CT ventilation studies: a Monte Carlo approach

Brett A. Simon1, Catherine Marcucci1, Mansheung Fung1 and Subhash R. Lele2

1 Department of Anesthesia and Critical Care Medicine, Johns Hopkins School of Medicine, and 2 Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, Maryland 21287

Simon, Brett A., Catherine Marcucci, Mansheung Fung, and Subhash R. Lele. Parameter estimation and confidence intervals for Xe-CT ventilation studies: a Monte Carlo approach. J. Appl. Physiol. 84(2): 709-716, 1998.---Xenon-enhanced computed tomography (Xe-CT) is a technique for the noninvasive measurement of regional pulmonary ventilation from the washin and/or washout time constants of radiodense stable xenon gas, determined from serial computed tomography scans. Although the measurement itself is straightforward, there is a need for methods for the estimation of variability and confidence intervals so that the statistical significance of the information obtained may be evaluated, particularly since obtaining repeated measurements is often not practical. We present a Monte Carlo (MC) approach to determine the 95% confidence interval (CI) for any given measurement. This MC method was characterized in terms of its unbiasedness and coverage of the CI. In addition, 10 identical Xe-CT ventilation runs were performed in an anesthetized dog, and the time constant was determined for several regions of varying size in each run. The 95% CI, estimated from these repeated measurements as the mean ± 2 × SE, compared favorably with the CI obtained by the MC approach. Finally, a simulation was performed to compare the performance of three imaging protocols in estimating model parameters.

xenon-enhanced computed tomography; lung imaging

The Journal of Applied Physiology 84(2):709-716
8750-7587/98 $5.00 Copyright © 1998 the American Physiological Society


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