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J Appl Physiol 84: 676-682, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 2, 676-682, February 1998

Skeletal muscle chemoreflex and pHi in exercise ventilatory control

David A. Oelberg1, Allison B. Evans1, Mirko I. Hrovat1, Paul P. Pappagianopoulos1, Samuel Patz2 and David M. Systrom1

1 Pulmonary and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114; and 2 Department of Radiology, Longwood Medical Research Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115

Oelberg, David A., Allison B. Evans, Mirko I. Hrovat, Paul P. Pappagianopoulos, Samuel Patz, and David M. Systrom. Skeletal muscle chemoreflex and pHi in exercise ventilatory control. J. Appl. Physiol. 84(2): 676-682, 1998.---To determine whether skeletal muscle hydrogen ion mediates ventilatory drive in humans during exercise, 12 healthy subjects performed three bouts of isotonic submaximal quadriceps exercise on each of 2 days in a 1.5-T magnet for 31P-magnetic resonance spectroscopy (31P-MRS). Bilateral lower extremity positive pressure cuffs were inflated to 45 Torr during exercise (BLPPex) or recovery (BLPPrec) in a randomized order to accentuate a muscle chemoreflex. Simultaneous measurements were made of breath-by-breath expired gases and minute ventilation, arterialized venous blood, and by 31P-MRS of the vastus medialis, acquired from the average of 12 radio-frequency pulses at a repetition time of 2.5 s. With BLPPex, end-exercise minute ventilation was higher (53.3 ± 3.8 vs. 37.3 ± 2.2 l/min; P < 0.0001), arterialized PCO2 lower (33 ± 1 vs. 36 ± 1 Torr; P = 0.0009), and quadriceps intracellular pH (pHi) more acid (6.44 ± 0.07 vs. 6.62 ± 0.07; P = 0.004), compared with BLPPrec. Blood lactate was modestly increased with BLPPex but without a change in arterialized pH. For each subject, pHi was linearly related to minute ventilation during exercise but not to arterialized pH. These data suggest that skeletal muscle hydrogen ion contributes to the exercise ventilatory response.

ventilation; lactic acid; magnetic resonance spectroscopy; intracellular pH

The Journal of Applied Physiology 84(2):676-682
8750-7587/98 $5.00 Copyright © 1998 the American Physiological Society


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