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J Appl Physiol 84: 612-617, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 2, 612-617, February 1998

Sympathetic discharge and vascular resistance after bed rest

J. Kevin Shoemaker1, Cynthia S. Hogeman1, Urs A. Leuenberger1, Michael D. Herr1, Kristen Gray1,2, David H. Silber1 and Lawrence I. Sinoway1,2

1 Division of Cardiology, The Pennsylvania State University College of Medicine, Hershey 17033; and 2 Lebanon Veterans Affairs Medical Center, Lebanon, Pennslyvania 17042

Shoemaker, J. Kevin, Cynthia S. Hogeman, Urs A. Leuenberger, Michael D. Herr, Kristen Gray, David H. Silber, and Lawrence I. Sinoway. Sympathetic discharge and vascular resistance after bed rest. J. Appl. Physiol. 84(2): 612-617, 1998.---The effect of -6° head-down-tilt bed rest (HDBR) for 14 days on supine sympathetic discharge and cardiovascular hemodynamics at rest was assessed. Mean arterial pressure, heart rate (n = 25), muscle sympathetic nerve activity (MSNA; n = 16) burst frequency, and forearm blood flow (n = 14) were measured, and forearm vascular resistance (FVR) was calculated. Stroke distance, our index of stroke volume, was derived from measurements of aortic mean blood velocity (Doppler) and R-R interval (n = 7). With these data, an index of total peripheral resistance was determined. Heart rate at rest was greater in the post (71 ± 2 beats/min)- compared with the pre-HDBR test (66 ± 2 beats/min; P < 0.003), but mean arterial pressure was unchanged. Aortic stroke distance during post-HDBR (15.5 ± 1.1 cm/beat) was reduced from pre-HDBR levels (20.0 ± 1.5 cm/beat) (P < 0.03). Also, MSNA burst frequency was reduced in the post (16.7 ± 2.8 beats/min)- compared with the pre (25.2 ± 2.6 beats/min)-HDBR condition (P < 0.01). Bed rest did not alter forearm blood flow, FVR, or total peripheral resistance. Thus reductions in MSNA with HDBR were not associated with a decrease in FVR.

muscle sympathetic nerve activity; forearm vascular resistance; total peripheral resistance; Doppler ultrasound

The Journal of Applied Physiology 84(2):612-617
8750-7587/98 $5.00 Copyright © 1998 the American Physiological Society


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