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Vol. 84, Issue 2, 612-617, February 1998
1 Division of Cardiology,
Shoemaker, J. Kevin, Cynthia S. Hogeman, Urs A. Leuenberger,
Michael D. Herr, Kristen Gray, David H. Silber, and Lawrence I. Sinoway. Sympathetic discharge and vascular resistance after bed
rest. J. Appl. Physiol. 84(2):
612-617, 1998.
The effect of 
6° head-down-tilt bed
rest (HDBR) for 14 days on supine sympathetic discharge and
cardiovascular hemodynamics at rest was assessed. Mean arterial
pressure, heart rate (n = 25), muscle
sympathetic nerve activity (MSNA; n = 16) burst frequency, and forearm blood flow
(n = 14) were measured, and forearm
vascular resistance (FVR) was calculated. Stroke distance,
our index of stroke volume, was derived from measurements of aortic
mean blood velocity (Doppler) and R-R interval
(n = 7). With these data, an index of
total peripheral resistance was determined. Heart rate at rest was
greater in the post (71 ± 2 beats/min)- compared with the pre-HDBR
test (66 ± 2 beats/min; P < 0.003), but mean arterial pressure was unchanged. Aortic stroke
distance during post-HDBR (15.5 ± 1.1 cm/beat) was reduced from
pre-HDBR levels (20.0 ± 1.5 cm/beat)
(P < 0.03). Also, MSNA burst
frequency was reduced in the post (16.7 ± 2.8 beats/min)- compared
with the pre (25.2 ± 2.6 beats/min)-HDBR condition
(P < 0.01). Bed rest did not alter
forearm blood flow, FVR, or total peripheral resistance. Thus
reductions in MSNA with HDBR were not associated with a decrease in
FVR.
muscle sympathetic nerve activity; forearm vascular resistance; total peripheral resistance; Doppler ultrasound
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