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Vol. 84, Issue 2, 584-592, February 1998
1 The John B. Pierce Laboratory, Department of Cellular and Molecular Physiology, and Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06519; and 2 Metabolism Unit, Shriners Burns Institute, and Departments of Surgery, Anesthesiology, and Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas 77550
Yang, Roger C., Gary W. Mack, Robert R. Wolfe, and Ethan R. Nadel. Albumin synthesis after intense intermittent exercise in
human subjects. J. Appl. Physiol.
84(2): 584-592, 1998.
We measured hepatic albumin synthesis in
five volunteers (4 men and 1 woman) at 3 and 6 h after recovery from
intense exercise. A primed-constant infusion of a stable isotopic
tracer of phenylalanine was used to determine hepatic fractional
synthetic rate (FSR) and absolute synthetic rate (ASR) of albumin from
the enrichment of phenylalanine in albumin. The infusion of the stable
isotope tracer began 2 h after upright exercise or upright rest.
Albumin FSR and ASR were 6.39 ± 0.48%/day and 120 ± 9 mg · kg body
wt
1 · day1,
respectively, 3-6 h after recovery from exercise; the FSR and ASR
on the time control study day were 5.94 ± 0.47%/day and 104 ± 9 mg · kg body
wt1 · day1,
respectively. The 6 and 16% increases
(P < 0.05) in FSR and ASR after
exercise were associated with an elevated plasma albumin content at 5 and 6 h of recovery (P < 0.05), an
increased total protein content throughout recovery
(P < 0.05), and a negative free
water clearance (P < 0.05) at 2, 3, and 6.5 h of recovery compared with baseline values; these variables
were unchanged from their baselines on the time control study day.
Increased albumin content and reduced free water clearance contribute
to a retention of fluid within the circulation after intense exercise. The measured increase in albumin synthesis could not account for the
entire increase in albumin content at 6 h of recovery from exercise.
However, we estimate that if the increased activity was maintained for
the next 18 h, it could account for the expected increase in albumin
content at 24 h of recovery.
blood volume; plasma volume; hypervolemia; stable isotopes; phenylalanine
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