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Vol. 84, Issue 2, 537-543, February 1998
1 Division of Clinical
Immunology,
Sanico, Alvin M., Satsuki Atsuta, David Proud, and Alkis
Togias. Plasma extravasation through neuronal stimulation in human
nasal mucosa in the setting of allergic rhinitis. J. Appl. Physiol. 84(2): 537-543, 1998.
We have
previously shown that capsaicin nasal challenge in subjects with
allergic rhinitis produces a dose-dependent increase in the albumin
content of nasal lavage fluids. In the present set of studies, we
determined whether this observation represents plasma extravasation
that is neuronally mediated. To evaluate whether glandular secretions
contribute to the albumin increase in nasal lavage fluids, volunteers
with allergic rhinitis were pretreated with atropine or placebo before capsaicin challenge. Atropine significantly reduced the volume of
returned lavage fluids and their lysozyme content but increased their
albumin and fibrinogen content. To assess the contribution of sensory
nerve stimulation, subjects with allergic rhinitis were pretreated in a
second study with lidocaine or placebo before capsaicin challenge.
Lidocaine significantly attenuated the capsaicin-induced increases in
the volume of nasal lavage fluids, as well as their lysozyme and
albumin content. To rule out the possibility of a direct effect of
lidocaine on blood vessels rather than on nerves, healthy subjects were
pretreated in a third study with lidocaine or placebo before bradykinin
nasal challenge. Lidocaine did not affect the bradykinin-induced
increase in the albumin content of nasal fluids. We conclude that, in
allergic rhinitis, high-dose capsaicin induces plasma extravasation in
the human nose and that this effect is neuronally mediated. This
provides more definitive evidence that neurogenic inflammation can
occur in vivo in the human upper airway.
capsaicin; neurogenic inflammation
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