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J Appl Physiol 84: 531-536, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 2, 531-536, February 1998

Sleep apnea in obese miniature pigs

Robert P. Lonergan III1, J. Catsby Ware2, Richard L. Atkinson3, W. Christopher Winter1 and Paul M. Suratt1

1 Pulmonary and Critical Care Medicine, University of Virginia Medical Center, Charlottesville 22908; 2 Department of Psychiatry and Behavioral Science, Eastern Virginia Medical School, Norfolk 23507; 3 Division of Endocrinology, Hampton Veterans Affairs Hospital, Hampton, Virginia 23667

Lonergan, Robert P., III, J. Catsby Ware, Richard L. Atkinson, W. Christopher Winter, and Paul M. Suratt. Sleep apnea in obese miniature pigs. J. Appl. Physiol. 84(2): 531-536, 1998.---We postulated that three extremely obese Yucatan miniature pigs would have more sleep apnea than three nonobese Yucatan miniature pigs. Pigs were studied with the use of electroencephalograms, inductance plethysmography, oximetry, expired nasal CO2, or thermistors. All of the obese pigs, but none of the nonobese pigs, had both sleep apnea (8.5, 10.3, and 97.0 in obese pigs vs. 0 apnea + hypopnea/h in all nonobese pigs; P < 0.05) and oxyhemoglobin desaturation episodes during sleep [9.4 ± 3.0 vs. 0 + 0.53 (SD) mean desaturation episodes/h in obese pigs vs. nonobese pigs, respectively; P < 0.05]. Two of the extremely obese pigs had obstructive sleep apnea, whereas the third obese pig had central sleep apnea. We conclude that sleep apnea occurs in extremely obese Yucatan minipigs and suggest that this animal can be used as a model for sleep apnea in obesity.

obstructive sleep apnea; central sleep apnea; obesity

The Journal of Applied Physiology 84(2):531-536


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