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Vol. 84, Issue 2, 499-506, February 1998
Department of Medicine, Division of Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224
Pedersen, Karen E., Sonya N. Meeker, Margerita M. Riccio,
and Bradley J. Undem. Selective stimulation of
jugular ganglion afferent neurons in guinea pig airways by hypertonic
saline. J. Appl. Physiol. 84(2):
499-506, 1998.
We evaluated the ability of hyperosmolar stimuli
to activate afferent nerves in the guinea pig trachea and main bronchi
and investigated the neural pathways involved. By using
electrophysiological techniques, studies in vitro examined the effect
of hyperosmolar solutions of sodium chloride (hypertonic saline) on
guinea pig airway afferent nerve endings arising from either vagal
nodose or jugular ganglia. The data reveal a differential sensitivity
of airway afferent neurons to activation with hypertonic saline.
Afferent fibers (both A
and C fibers) with cell bodies located in
jugular ganglia were much more sensitive to stimulation with hypertonic
saline, compared with afferent neurons with cell bodies located in
nodose ganglia. Additional studies in vivo demonstrated that inhalation
of aerosols of hypertonic saline induced plasma extravasation in guinea
pig trachea that was mediated via tachykinin
NK1 receptors. Identification of a
differential sensitivity of guinea pig airway afferent nerves to
hypertonic saline leads to the speculation that airway responses to
hyperosmolar stimuli may result from activation of afferent neurons
originating predominantly from the jugular ganglion.
osmolar concentration; vagus nerve; tachykinin; neuropeptides; asthma
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