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Vol. 84, Issue 2, 465-470, February 1998
Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville 3052; Department of Human Movement Science, Royal Melbourne Institute of Technology, Bundoora 3083; and School of Human Movement, Deakin University, Burwood 3125, Australia
Febbraio, M. A., D. L. Lambert, R. L. Starkie, J. Proietto,
and M. Hargreaves. Effect of epinephrine on muscle glycogenolysis during exercise in trained men. J. Appl.
Physiol. 84(2): 465-470, 1998.
To test the
hypothesis that an elevation in circulating epinephrine increases
intramuscular glycogen utilization, six endurance-trained men performed
two 40-min cycling trials at 71 ± 2% of peak oxygen uptake in
20-22°C conditions. On the first occasion, subjects were
infused with saline throughout exercise (Con). One week later, after
determination of plasma epinephrine levels in Con, subjects performed
the second trial (Epi) with an epinephrine infusion, which resulted in
a twofold higher (P < 0.01) plasma
epinephrine concentration in Epi compared with Con. Although oxygen
uptake was not different when the two trials were compared, respiratory
exchange ratio was higher throughout exercise in Epi compared with Con
(0.93 ± 0.01 vs. 0.89 ± 0.01; P < 0.05). Muscle glycogen
concentration was not different when the trials were compared
preexercise, but the postexercise value was lower
(P < 0.01) in Epi compared with Con.
Thus net muscle glycogen utilization was greater during exercise with
epinephrine infusion (224 ± 37 vs. 303 ± 30 mmol/kg for Con and
Epi, respectively; P < 0.01). In
addition, both muscle and plasma lactate and plasma glucose
concentrations were higher (P < 0.05) in Epi compared with Con. These data indicate that intramuscular
glycogen utilization, glycolysis, and carbohydrate oxidation are
augmented by elevated epinephrine during submaximal exercise in trained
men.
catecholamines; carbohydrate metabolism; training
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