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Vol. 84, Issue 2, 454-458, February 1998
1 Departments of
Anesthesiology,
Halliwill, John R., Lori A. Lawler, Tamara J. Eickhoff,
Michael J. Joyner, and Sharon L. Mulvagh. Reflex responses to
regional venous pooling during lower body negative pressure in humans.
J. Appl. Physiol. 84(2): 454-458, 1998.
Lower body negative pressure is frequently used to simulate
orthostasis. Prior data suggest that venous pooling in abdominal or
pelvic regions may have major hemodynamic consequences. Therefore, we developed a simple paradigm for assessing regional contributions to
venous pooling during lower body negative pressure. Sixteen healthy men
and women underwent graded lower body negative pressure protocols to 60 mmHg while wearing medical antishock trousers to prevent venous pooling
under three randomized conditions:
1) no trouser inflation (control),
2) only the trouser legs inflated, and 3) the trouser legs and
abdominopelvic region inflated. Without trouser inflation, heart rate
increased 28 ± 4 beats/min, mean arterial pressure fell 
3 ± 2 mmHg, and forearm vascular resistance increased 51 ± 9 units at 60 mmHg lower body negative pressure. With inflation of either
the trouser legs or the trouser legs and abdominopelvic region, heart
rate and mean arterial pressure did not change during lower body
negative pressure. By contrast, although the forearm vasoconstrictor
response to lower body negative pressure was attenuated by inflation of
the trouser legs (
forearm vascular resistance 33 ± 10 units,
P < 0.05 vs. control), attenuation was greater with the inflation of the trouser legs and abdominopelvic region (forearm vascular resistance 16 ± 5 units,
P < 0.05 vs. control and trouser
legs-only inflation). Thus the hemodynamic consequences of pooling in
the abdominal and pelvic regions during lower body negative pressure
appear to be less than in the legs in healthy individuals.
blood pooling; orthostasis; cardiopulmonary reflex; arterial baroreflex
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