| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Vol. 84, Issue 2, 435-441, February 1998
1 Department of Anesthesia and Critical Care, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114; and 2 National Cancer Institute, Frederick, Maryland 21702
Adrie, Christophe, Fumito Ichinose, Alexandra
Holzmann, Larry Keefer, William E. Hurford, and Warren M. Zapol. Pulmonary vasodilation by nitric oxide gas and prodrug
aerosols in acute pulmonary hypertension. J. Appl. Physiol. 84(2): 435-441, 1998.
Sodium 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate
{DEA/NO;
Et2N[N(O)NO]Na} is a compound that spontaneously generates nitric oxide (NO). Because
of its short half-life (2.1 min), we hypothesized that inhaling DEA/NO
aerosol would selectively dilate the pulmonary circulation without
decreasing systemic arterial pressure. We compared the pulmonary
selectivity of this new NO donor with two other reference drugs:
inhaled NO and inhaled sodium nitroprusside (SNP). In seven awake sheep
with pulmonary hypertension induced by the infusion of U-46619, we
compared the hemodynamic effects of DEA/NO with those of incremental
doses of inhaled NO gas. In seven additional awake sheep, we examined
the hemodynamic effects of incremental doses of inhaled nitroprusside
(i.e., SNP). Inhaled NO gas selectively dilated the pulmonary
vasculature. Inhaled DEA/NO produced nonselective vasodilation; both
systemic vascular resistance (SVR) and pulmonary vascular resistance
(PVR) were reduced. Inhaled SNP selectively dilated the pulmonary
circulation at low concentrations
(
10
2 M), inducing a
decrease of PVR of up to 42% without any significant decrease of SVR
(
5%), but nonselectively dilated the systemic circulation at
larger doses (>102 M). In
conclusion, despite its short half-life, DEA/NO is not a selective
pulmonary vasodilator compared with inhaled NO. Inhaled SNP appears to
be selective to the pulmonary circulation at low doses but not at
higher levels.
nitric oxide adducts; sodium nitroprusside; sheep
This article has been cited by other articles:
|
|
 |
|
  I. M. Lang Management of acute and chronic RV dysfunction Eur. Heart J. Suppl., December 1, 2007; 9(suppl_H): H61 - H67. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Subramaniam and J.-P. Yared Management of Pulmonary Hypertension in the Operating Room Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2007; 11(2): 119 - 136. [Abstract] [PDF]
|
|
|
|
 |
|
 M. J.D. Griffiths and T. W. Evans Inhaled Nitric Oxide Therapy in Adults N. Engl. J. Med., December 22, 2005; 353(25): 2683 - 2695. [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Lam, P. V. van Heerden, K. F. Ilett, P. Caterina, and P. Filion Two Aerosolized Nitric Oxide Adducts as Selective Pulmonary Vasodilators for Acute Pulmonary Hypertension Chest, March 1, 2003; 123(3): 869 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Y. Kirov, O. V. Evgenov, V. N. Kuklin, L. Virag, P. Pacher, G. J. Southan, A. L. Salzman, C. Szabo, and L. J. Bjertnaes Aerosolized Linear Polyethylenimine-Nitric Oxide/Nucleophile Adduct Attenuates Endotoxin-induced Lung Injury in Sheep Am. J. Respir. Crit. Care Med., December 1, 2002; 166(11): 1436 - 1442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Stuesse, G. D. Giraud, A. A. Vlessis, A. Starr, and D. D. Trunkey Hemodynamic effects of S-nitrosocysteine, an intravenous regional vasodilator J. Thorac. Cardiovasc. Surg., August 1, 2001; 122(2): 371 - 377. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
