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Vol. 84, Issue 1, 303-310, January 1998
Departments of Anesthesia, Physiology/Biophysics, Pediatrics, and Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202; Department of Physiology, Medical College of Wisconsin, Milwaukee 53226; Research Service, Zablocki Veterans Affairs Medical Center, Milwaukee 53295; and Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin 53233
Presson, Robert G., Jr., Said H. Audi, Christopher C. Hanger, Gerald M. Zenk, Richard A. Sidner, John H. Linehan, Wiltz W. Wagner, Jr., and Christopher A. Dawson. Anatomic distribution of
pulmonary vascular compliance. J. Appl.
Physiol. 84(1): 303-310, 1998.
Previously, the
pressure changes after arterial and venous occlusion have been used to
characterize the longitudinal distribution of pulmonary vascular
resistance with respect to vascular compliance using compartmental
models. However, the compartments have not been defined anatomically.
Using video microscopy of the subpleural microcirculation, we have
measured the flow changes in ~40-µm arterioles and venules after
venous, arterial, and double occlusion maneuvers. The quasi-steady
flows through these vessels after venous occlusion permitted an
estimation of the compliance in three anatomic segments: arteries >40
µm, veins >40 µm, and vessels <40 µm in diameter. We found
that ~65% of the total pulmonary vascular compliance was in vessels
<40 µm, presumably mostly capillaries. The transient portions of
the pressure and flow data after venous, arterial, and double occlusion
were consistent with most of the arterial compliance being upstream
from most of the arterial resistance and most of the venous compliance
being downstream from most of the venous resistance.
pulmonary microcirculation; arterial occlusion; venous occlusion; double occlusion; video fluorescence microscopy; digital image analysis; fluorescently labeled red blood cells; vascular resistance; mathematical model; isolated dog lung
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