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Vol. 84, Issue 1, 30-36, January 1998
Institute of Physiology, School of Medicine and Life Science, National Yang-Ming University, Taipei, Taiwan 11221, Republic of China
Lai, C. J., and Y. R. Kou. Stimulation of vagal
pulmonary C fibers by inhaled wood smoke in rats. J. Appl. Physiol. 84(1): 30-36, 1998.
This study
investigated the stimulation of vagal pulmonary C fibers (PCs) by wood
smoke. We recorded impulses from PCs in 58 anesthetized, open-chest,
and artificially ventilated rats and delivered 6 ml of wood smoke into
the lungs. Within 1 or 2 s after the smoke delivery, an intense and
nonphasic burst of discharge [
= +7.4 ± 0.7 (SE)
impulses/s, n = 68] was evoked in 60 of the 68 PCs studied and lasted for 4-8 s. This immediate stimulation was usually followed by a delayed and more sustained increase in C-fiber activity ( = +2.0 ± 0.4 impulses/s). The overall stimulation was not influenced by removal of smoke particulates (n = 15) or by pretreatment with
vehicle (n = 8) for dimethylthiourea (DMTU; a hydroxyl radical scavenger) or indomethacin (Indo; a cyclooxygenase inhibitor). The immediate-phase stimulation was not
affected by pretreatment with Indo (n = 8) but was largely attenuated by pretreatment with DMTU
(n = 12) or by a combined treatment
with DMTU and Indo (DMTU+Indo; n = 8).
Conversely, the delayed-phase stimulation was partially suppressed
either by DMTU or by Indo but was totally abolished by DMTU+Indo. These
results suggest that 1) the
stimulation of PCs is linked to the gas phase of wood smoke and
2) hydroxyl radical, but not
cyclooxygenase products, is involved in the immediate-phase
stimulation, whereas both metabolites are responsible for evoking the
delayed-phase stimulation.
lung vagal sensory receptors; gas phase; particulates; dimethylthiourea; indomethacin
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