Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 84: 253-256, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 1, 253-256, January 1998

Mechanism controlling sleep organization of the obese Zucker rats

David Megirian1, Jacek Dmochowski2, and Gaspar A. Farkas1

1 Department of Physical Therapy, Exercise and Nutrition Science, School of Health Related Professions, and 2 Department of Statistics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14214-3079

Megirian, David, Jacek Dmochowski, and Gaspar A. Farkas. Mechanism controlling sleep organization of the obese Zucker rat. J. Appl. Physiol. 84(1): 253-256, 1998.---We tested the hypothesis that the obese (fa/fa) Zucker rat has a sleep organization that differs from that of lean Zucker rats. We used the polygraphic technique to identify and to quantify the distribution of the three main states of the rat: wakefulness (W), non-rapid-eye-movement (NREM), and rapid-eye-movement (REM) sleep states. Assessment of states was made with light present (1000-1600), at the rats thermoneutral temperature of 29°C. Obese rats, compared with lean ones, did not show significant differences in the total time spent in the three main states. Whereas the mean durations of W and REM states did not differ statistically, that of NREM did (P = 0.046). However, in the obese rats, the frequencies of switching from NREM sleep to W, which increased, and from NREM to REM sleep, which decreased, were statistically significantly different (P = 0.019). Frequency of switching from either REM or W state was not significantly different. We conclude that sleep organization differs between lean and obese Zucker rats and that it is due to a disparity in switching from NREM sleep to either W or REM sleep and the mean duration of NREM sleep.

switching of states; duration of states; ventilatory factor; thermoregulatory factor

The Journal of Applied Physiology 84(1):253-256
0161-7567/98 $5.00 Copyright © 1998 the American Physiological Society


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