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J Appl Physiol 84: 244-252, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 1, 244-252, January 1998

Multiple-breath washin of helium and sulfur hexafluoride in sustained microgravity

G. Kim Prisk, Ann R. Elliott, Harold J. B. Guy, Sylvia Verbanck, Manuel Paiva, and John B. West

Department of Medicine, University of California, San Diego, La Jolla, California 92093; Akademisch Ziekenhuis, Vrije Universiteit Brussel, 1090 Brussels; and Biomedical Physics Laboratory, Université Libre de Bruxelles, 1070 Brussels, Belgium

Prisk, G. Kim, Ann R. Elliott, Harold J. B. Guy, Sylvia Verbanck, Manuel Paiva, and John B. West. Multiple-breath washin of helium and sulfur hexafluoride in sustained microgravity. J. Appl. Physiol. 84(1): 244-252, 1998.---We performed multiple-breath washouts of N2 and simultaneous washins of He and SF6 with fixed tidal volume (~1,250 ml) and preinspiratory lung volume (approximately the subject's functional residual capacity in the standing position) in four normal subjects (mean age 40 yr) standing and supine in normal gravity (1 G) and during exposure to sustained microgravity (µG). The primary objective was to examine the influence of diffusive processes on the residual, nongravitational ventilatory inhomogeneity in the lung in µG. We calculated several indexes of convective ventilatory inhomogeneity from each gas species. A normal degree of ventilatory inhomogeneity was seen in the standing position at 1 G that was largely unaltered in the supine position. When we compared the standing position in 1 G with µG, there were reductions in phase III slope in all gases, consistent with a reduction in convection-dependent inhomogeneity in the lung in µG, although considerable convective inhomogeneity persisted in µG. The reductions in the indexes of convection-dependent inhomogeneity were greater for He than for SF6, suggesting that the distances between remaining nonuniformly ventilated compartments in µG were short enough for diffusion of He to be an effective mechanism to reduce gas concentration differences between them.

humans; spaceflight; zero gravity; distribution of pulmonary ventilation; phase III of expiration; specific ventilation; intra-acinar inhomogeneity; convective inhomogeneity

The Journal of Applied Physiology 84(1):244-252
0161-7567/98 $5.00 Copyright © 1998 the American Physiological Society


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