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J Appl Physiol 84: 19-29, 1998;
8750-7587/98 $5.00
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Vol. 84, Issue 1, 19-29, January 1998

Choroidal readaptation to gravity in rats after spaceflight and head-down tilt

Julien Davet1, Benoit Clavel1, Lucien Datas2, Laurence Mani-Ponset1, Daniel Maurel1, Serge Herbuté1, Michel Viso3, William Hinds4, Joellen Jarvi4, and Jacqueline Gabrion1

1 Dynamique Moléculaire des Interactions Membranaires, Unité Mixte de Recherche 5539, Centre National de la Recherche Scientifique, and 2 Service Commun de Microscopie Electronique, Université de Montpellier II, Sciences et Techniques du Languedoc, Montpellier F34095; 3 Centre National d'Etudes Spatiales, Direction des Programmes, Paris F75001, France; and 4 Ames Research Center, National Aeronautics and Space Administration, Moffett Field, California 95034

Davet, Julien, Benoit Clavel, Lucien Datas, Laurence Mani-Ponset, Daniel Maurel, Serge Herbuté, Michel Viso, William Hinds, Joellen Jarvi, and Jacqueline Gabrion. Choroidal readaptation to gravity in rats after spaceflight and head-down tilt. J. Appl. Physiol. 84(1): 19-29, 1998.---To determine when choroidal structures were restored after readaptation to Earth gravity or orthostatic position, fine structure and protein distribution were studied in rat choroid plexus dissected either 6 h [Space Life Sciences-2 (SLS-2) experiments] or 2 days [National Institutes of Health-Rodent 1 (NIH-R1) experiments] after a spaceflight, or 6 h after head-down tilt (HDT) experiments. Apical alterations were noted in choroidal cells from SLS-2 and HDT animals, confirming that weightlessness impaired choroidal structures and functions. However, the presence of small apical microvilli and kinocilia and the absence of vesicle accumulations showed that the apical organization began to be restored rapidly after landing. Very enlarged apical microvilli appeared after 2 days on Earth, suggesting increased choroidal activity. However, as distributions of ezrin and carbonic anhydrase II remained altered in both flight and suspended animals after readaptation to Earth gravity, it was concluded that choroidal structures and functions were not completely restored, even after 2 days in Earth's gravity.

choroid plexus; microvilli; ezrin; carbonic anhydrase II; electron microscopy; immunocytochemistry

The Journal of Applied Physiology 84(1):19-29
0161-7567/98 $5.00 Copyright © 1998 the American Physiological Society


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