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J Appl Physiol 83: 2080-2085, 1997;
8750-7587/97 $5.00
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Vol. 83, Issue 6, 2080-2085, December 1997

Effects of chronic exercise and deconditioning on platelet function in women

Jong-Shyan Wang, Chauying J. Jen, and Hsiun-Ing Chen

Department of Physiology, National Cheng-Kung University Medical College, Tainan, Taiwan 701, Republic of China

Received 25 March 1997; accepted in final form 28 July 1997.

Wang, Jong-Shyan, Chauying J. Jen, and Hsiun-Ing Chen. Effects of chronic exercise and deconditioning on platelet function in women. J. Appl. Physiol. 83(6): 2080-2085, 1997.---To investigate the effects of chronic exercise and deconditioning on platelet function in women, 16 healthy sedentary women were divided into control and exercise groups. The exercise group cycled on an ergometer at 50% maximal oxygen consumption for 30 min/day, 5 days/wk, for two consecutive menstrual cycles and then were deconditioned for three menstrual cycles. During this period, platelet adhesiveness on a fibrinogen-coated surface, ADP-induced platelet aggregation and intracellular calcium concentration elevation, guanosine 3',5'-cyclic monophosphate (cGMP) content in platelets, and plasma nitric oxide metabolite levels were measured before and immediately after a progressive exercise test in the midfollicular phase. Our results indicated that, after exercise training, 1) resting heart rates and blood pressures were reduced, and exercise performance was improved; 2) resting platelet function was decreased, whereas plasma nitrite and nitrate levels and platelet cGMP contents were enhanced; and 3) the potentiation of platelet function by acute strenuous exercise was decreased, whereas the increases in plasma nitrite and nitrate levels and platelet cGMP contents were enhanced by acute exercise. Furthermore, deconditioning reversed these training effects. This implies that training-induced platelet functional changes in women in the midfollicular phase may be mediated by nitric oxide.

platelet adhesion; aggregation; nitric oxide; midfollicular phase; guanosine 3',5'-cyclic monophosphate

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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