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J Appl Physiol 83: 2055-2063, 1997;
8750-7587/97 $5.00
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Vol. 83, Issue 6, 2055-2063, December 1997

Long-term creatine intake is beneficial to muscle performance during resistance training

K. Vandenberghe1, M. Goris1, P. Van Hecke2, M. Van Leemputte1, L. Vangerven3, and P. Hespel1

1 Department of Kinesiology, Faculty of Physical Education and Physiotherapy, and 2 Biomedical Nuclear Magnetic Resonance Unit, Department of Radiology, Faculty of Medicine, Katholieke Universiteit Leuven; and 3 Department Rega School, Katholieke Hogeschool Leuven, B-3001 Leuven, Belgium

Received 13 March 1997; accepted in final form 30 July 1997.

Vandenberghe, K., M. Goris, P. Van Hecke, M. Van Leemputte, L. Vangerven, and P. Hespel. Long-term creatine intake is beneficial to muscle performance during resistance training. J. Appl. Physiol. 83(6): 2055-2063, 1997.---The effects of oral creatine supplementation on muscle phosphocreatine (PCr) concentration, muscle strength, and body composition were investigated in young female volunteers (n = 19) during 10 wk of resistance training (3 h/wk). Compared with placebo, 4 days of high-dose creatine intake (20 g/day) increased (P < 0.05) muscle PCr concentration by 6%. Thereafter, this increase was maintained during 10 wk of training associated with low-dose creatine intake (5 g/day). Compared with placebo, maximal strength of the muscle groups trained, maximal intermittent exercise capacity of the arm flexors, and fat-free mass were increased 20-25, 10-25, and 60% more (P < 0.05), respectively, during creatine supplementation. Muscle PCr and strength, intermittent exercise capacity, and fat-free mass subsequently remained at a higher level in the creatine group than in the placebo group during 10 wk of detraining while low-dose creatine was continued. Finally, on cessation of creatine intake, muscle PCr in the creatine group returned to normal within 4 wk. It is concluded that long-term creatine supplementation enhances the progress of muscle strength during resistance training in sedentary females.

phosphorus-31-nuclear magnetic resonance; ergogenics; diet; intermittent exercise

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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