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Vol. 83, Issue 6, 2037-2042, December 1997
Departments of Anesthesiology and Physiology, Veterans Affairs Medical Center and Medical College of Wisconsin, Milwaukee, Wisconsin 53295
Received 27 May 1997; accepted in final form 18 August 1997.
Buckwalter, John B., Patrick J. Mueller, and Philip S. Clifford. Autonomic control of skeletal muscle vasodilation during
exercise. J. Appl. Physiol. 83(6):
2037-2042, 1997.
Despite extensive investigation, the control of
blood flow during dynamic exercise is not fully understood. The purpose
of this study was to determine whether 
-adrenergic or muscarinic
receptors are involved in the vasodilation in exercising skeletal
muscle. Six mongrel dogs were instrumented with ultrasonic flow probes
on both external iliac arteries and with a catheter in a branch of one
femoral artery. The dogs exercised on a treadmill at 6 miles/h while
drugs were injected intra-arterially into one hindlimb. Isoproterenol
(0.2 µg) or acetylcholine (1 µg) elicited increases in iliac blood
flow of 89.8 ± 14.4 and 95.6 ± 17.4%, respectively, without
affecting systemic blood pressure or blood flow in the contralateral
iliac artery. Intra-arterial propranolol (1 mg) or atropine (500 µg)
had no effect on iliac blood flow, although they abolished the
isoproterenol and acetylcholine-induced increases in iliac blood flow.
These data indicate that exogenous activation of -adrenergic or
muscarinic receptors in the hindlimb vasculature increases blood flow
to dynamically exercising muscle. More importantly, because neither
propranolol nor atropine affected iliac blood flow, we conclude that
-adrenergic and muscarinic receptors are not involved in the control
of blood flow to skeletal muscle during moderate steady-state dynamic
exercise in dogs.
blood flow; acetylcholine; muscarinic; -adrenergic; dogs
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J. B. Buckwalter, S. B. Ruble, P. J. Mueller, and P. S. Clifford Skeletal muscle vasodilation at the onset of exercise J Appl Physiol, November 1, 1998; 85(5): 1649 - 1654. [Abstract] [Full Text] [PDF]
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C. K. Dyke, N. M. Dietz, R. L. Lennon, D. O. Warner, and M. J. Joyner Forearm blood flow responses to handgripping after local neuromuscular blockade J Appl Physiol, February 1, 1998; 84(2): 754 - 758. [Abstract] [Full Text] [PDF]
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