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Vol. 83, Issue 6, 2029-2036, December 1997
1 Department of Medicine, University of California, San Diego, La Jolla, California 92093-0931; and 2 Biomedical Physics Laboratory, Université Libre de Bruxelles, Brussels, Belgium
Received 24 March 1997; accepted in final form 20 August 1997.
Darquenne, Chantal, Manuel Paiva, John B. West, and G. Kim
Prisk. Effect of microgravity and hypergravity on deposition of
0.5- to 3-µm-diameter aerosol in the human lung. J. Appl. Physiol. 83(6): 2029-2036, 1997.
We
measured intrapulmonary deposition of 0.5-, 1-, 2-, and 3-µm-diameter
particles in four subjects on the ground (1 G) and during parabolic
flights both in microgravity (µG) and at ~1.6 G. Subjects breathed aerosols at a constant flow rate (0.4 l/s) and tidal
volume (0.75 liter). At 1 G and ~1.6 G, deposition increased with
increasing particle size. In µG, differences in deposition as a
function of particle size were almost abolished. Deposition was a
nearly linear function of the G level for 2- and 3-µm-diameter
particles, whereas for 0.5- and 1.0-µm-diameter particles, deposition
increased less between µG and 1 G than between 1 G and ~1.6 G. Comparison with numerical predictions showed good agreement for 1-, 2-, and 3-µm-diameter particles at 1 and ~1.6 G, whereas the model
consistently underestimated deposition in µG. The higher deposition
observed in µG compared with model predictions might be explained by
a larger deposition by diffusion because of a higher alveolar
concentration of aerosol in µG and to the nonreversibility of the
flow, causing additional mixing of the aerosols.
aerosol deposition; gravity; human lung
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