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Vol. 83, Issue 6, 2012-2018, December 1997
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7756
Received 28 April 1997; accepted in final form 4 August 1997.
Charkoudian, Nisha, and John M. Johnson. Modification
of active cutaneous vasodilation by oral contraceptive hormones. J. Appl. Physiol. 83(6):
2012-2018, 1997.
It is not clear whether the altered
thermoregulatory reflex control of the cutaneous circulation seen among
phases of the menstrual cycle also occurs with the synthetic estrogen
and progesterone in oral contraceptive pills and whether any such
modifications include altered control of the cutaneous active
vasodilator system. To address these questions, we conducted controlled
whole body heating experiments in seven women at the end of the third
week of hormone pills (HH) and at the end of the week of placebo/no
pills (LH). A water-perfused suit was used to control body temperature.
Laser Doppler flowmetry was used to monitor cutaneous blood flow at a
control site and at a site at which noradrenergic vasoconstrictor
control had been eliminated by iontophoresis of bretylium (BT),
isolating the active cutaneous vasodilator system. The oral temperature
(Tor) thresholds for cutaneous
vasodilation were higher in HH at both control [37.09 ± 0.12 vs. 36.83 ± 0.07°C (LH), P < 0.01] and BT-treated [37.19 ± 0.05 vs. 36.88 ± 0.12°C (LH), P < 0.01]
sites. The Tor threshold for
sweating was similarly shifted (HH: 37.15 ± 0.11°C vs. LH: 36.94 ± 0.11°C, P < 0.01). A
rightward shift in the relationship of heart rate to
Tor was seen in HH. The
sensitivities (slopes of the responses vs.
Tor) did not differ
statistically between phases. The similar threshold shifts at control
and BT-treated sites suggest that the hormones shift the function of
the active vasodilator system to higher internal temperatures. The
similarity of the shifts among thermoregulatory effectors suggests a
centrally mediated action of these hormones.
skin blood flow; estrogen; progesterone; heat stress; active vasodilation; bretylium; laser Doppler flowmetry; sweat rate; heart rate; human
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