| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Vol. 83, Issue 6, 2012-2018, December 1997
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7756
Received 28 April 1997; accepted in final form 4 August 1997.
Charkoudian, Nisha, and John M. Johnson. Modification
of active cutaneous vasodilation by oral contraceptive hormones. J. Appl. Physiol. 83(6):
2012-2018, 1997.
It is not clear whether the altered
thermoregulatory reflex control of the cutaneous circulation seen among
phases of the menstrual cycle also occurs with the synthetic estrogen
and progesterone in oral contraceptive pills and whether any such
modifications include altered control of the cutaneous active
vasodilator system. To address these questions, we conducted controlled
whole body heating experiments in seven women at the end of the third
week of hormone pills (HH) and at the end of the week of placebo/no
pills (LH). A water-perfused suit was used to control body temperature.
Laser Doppler flowmetry was used to monitor cutaneous blood flow at a
control site and at a site at which noradrenergic vasoconstrictor
control had been eliminated by iontophoresis of bretylium (BT),
isolating the active cutaneous vasodilator system. The oral temperature
(Tor) thresholds for cutaneous
vasodilation were higher in HH at both control [37.09 ± 0.12 vs. 36.83 ± 0.07°C (LH), P < 0.01] and BT-treated [37.19 ± 0.05 vs. 36.88 ± 0.12°C (LH), P < 0.01]
sites. The Tor threshold for
sweating was similarly shifted (HH: 37.15 ± 0.11°C vs. LH: 36.94 ± 0.11°C, P < 0.01). A
rightward shift in the relationship of heart rate to
Tor was seen in HH. The
sensitivities (slopes of the responses vs.
Tor) did not differ
statistically between phases. The similar threshold shifts at control
and BT-treated sites suggest that the hormones shift the function of
the active vasodilator system to higher internal temperatures. The
similarity of the shifts among thermoregulatory effectors suggests a
centrally mediated action of these hormones.
skin blood flow; estrogen; progesterone; heat stress; active vasodilation; bretylium; laser Doppler flowmetry; sweat rate; heart rate; human
This article has been cited by other articles:
|
|
 |
|
  G. P. Kenny, E. Leclair, R. J. Sigal, W. S. Journeay, D. Kilby, L. Nettlefold, F. D. Reardon, and O. Jay Menstrual cycle and oral contraceptive use do not modify postexercise heat loss responses J Appl Physiol, October 1, 2008; 105(4): 1156 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Sims, N. J. Rehrer, M. L. Bell, and J. D. Cotter Preexercise sodium loading aids fluid balance and endurance for women exercising in the heat J Appl Physiol, August 1, 2007; 103(2): 534 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. McCord, J.-L. Cracowski, and C. T. Minson Prostanoids contribute to cutaneous active vasodilation in humans Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R596 - R602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Wick, S. K. Roberts, A. Basu, P. Sandroni, R. D. Fealey, D. Sletten, and N. Charkoudian Delayed threshold for active cutaneous vasodilation in patients with Type 2 diabetes mellitus J Appl Physiol, February 1, 2006; 100(2): 637 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. McCord and C. T. Minson Cutaneous vascular responses to isometric handgrip exercise during local heating and hyperthermia J Appl Physiol, June 1, 2005; 98(6): 2011 - 2018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Armstrong, C. M. Maresh, N. R. Keith, T. A. Elliott, J. L. VanHeest, T. P. Scheett, J. Stoppani, D. A. Judelson, and M. J. De Souza Heat acclimation and physical training adaptations of young women using different contraceptive hormones Am J Physiol Endocrinol Metab, May 1, 2005; 288(5): E868 - E875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Michikami, A. Kamiya, Q. Fu, S. Iwase, T. Mano, and K. Sunagawa Attenuated thermoregulatory sweating and cutaneous vasodilation after 14-day bed rest in humans J Appl Physiol, January 1, 2004; 96(1): 107 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Charkoudian Skin Blood Flow in Adult Human Thermoregulation: How It Works, When It Does Not, and Why Mayo Clin. Proc., May 1, 2003; 78(5): 603 - 612. [Abstract] [PDF]
|
|
|
|
 |
|
 L. A. Holowatz, B. L. Houghton, B. J. Wong, B. W. Wilkins, A. W. Harding, W. L. Kenney, and C. T. Minson Nitric oxide and attenuated reflex cutaneous vasodilation in aged skin Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1662 - H1667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Stephens, L. A. T. Bennett, K. Aoki, W. A. Kosiba, N. Charkoudian, and J. M. Johnson Sympathetic nonnoradrenergic cutaneous vasoconstriction in women is associated with reproductive hormone status Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H264 - H272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Aoki, D. P. Stephens, and J. M. Johnson Diurnal variation in cutaneous vasodilator and vasoconstrictor systems during heat stress Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2001; 281(2): R591 - R595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Charkoudian, B. Fromy, and J.-L. Saumet Reflex control of the cutaneous circulation after acute and chronic local capsaicin J Appl Physiol, May 1, 2001; 90(5): 1860 - 1864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Brooks-Asplund, J. G. Cannon, and W. L. Kenney Influence of hormone replacement therapy and aspirin on temperature regulation in postmenopausal women Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R839 - R848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Dunbar and W. L. Kenney Effects of hormone replacement therapy on hemodynamic responses of postmenopausal women to passive heating J Appl Physiol, July 1, 2000; 89(1): 97 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Stachenfeld, C. Silva, and D. L. Keefe Estrogen modifies the temperature effects of progesterone J Appl Physiol, May 1, 2000; 88(5): 1643 - 1649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Charkoudian, D. P. Stephens, K. C. Pirkle, W. A. Kosiba, and J. M. Johnson Influence of female reproductive hormones on local thermal control of skin blood flow J Appl Physiol, November 1, 1999; 87(5): 1719 - 1723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Charkoudian and J. M. Johnson Reflex control of cutaneous vasoconstrictor system is reset by exogenous female reproductive hormones J Appl Physiol, July 1, 1999; 87(1): 381 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Charkoudian and J. M. Johnson Altered reflex control of cutaneous circulation by female sex steroids is independent of prostaglandins Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1634 - H1640. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
