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Vol. 83, Issue 6, 1998-2004, December 1997
1 Departments of Radiology and
Neurology,
Received 23 January 1997; accepted in final form 4 August 1997.
Kent-Braun, J. A., A. V. Ng, M. Castro, M. W. Weiner, D. Gelinas, G. A. Dudley, and R. G. Miller. Strength, skeletal muscle
composition and enzyme activity in multiple sclerosis. J. Appl. Physiol. 83(6):
1998-2004, 1997.
fiber types; biopsy; magnetic resonance imaging; magnetic resonance
spectroscopy; disuse; fatigue
This study examined functional, biochemical, and
morphological characteristics of skeletal muscle in nine multiple
sclerosis (MS) patients and eight healthy controls in an effort to
ascertain whether intramuscular adaptations could account for excessive
fatigue in this disease. Analyses of biopsies of the tibialis anterior
muscle showed that there were fewer type I fibers (66 ± 6 vs. 76 ± 6%), and that fibers of all types were smaller (average
26%) and had lower succinic dehydrogenase (SDH; average
40%) and SDH/
-glycerol-phosphate dehydrogenase (GPDH) but
not GPDH activities in MS vs. control subjects, suggesting that muscle
in this disease is smaller and relies more on anaerobic than
aerobic-oxidative energy supply than does muscle of healthy
individuals. Maximal voluntary isometric force for
dorsiflexion was associated with both average fiber cross-sectional
area (r = 0.71, P = 0.005) and muscle fat-free cross-sectional area by magnetic resonance imaging
(r = 0.80, P < 0.001). Physical activity,
assessed by accelerometer, was associated with average fiber SDH/GPDH
(r = 0.78, P = 0.008). There was a tendency for
symptomatic fatigue to be inversely associated with average fiber SDH
activity (r = 
0.57,
P = 0.068). The results of this
study suggest that the inherent characteristics of skeletal muscle
fibers per se and of skeletal muscle as a whole are altered in the
direction of disuse in MS. They also suggest that changes in skeletal
muscle in MS may significantly affect function.
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society
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