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J Appl Physiol 83: 1954-1961, 1997;
8750-7587/97 $5.00
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Vol. 83, Issue 6, 1954-1961, December 1997

Cardiopulmonary control in sleeping Sprague-Dawley rats treated with hydralazine

David W. Carley1,2, Sinisa M. Trbovic2, Alex Bozanich1, and Miodrag Radulovacki2

1 Section of Respiratory and Critical Care Medicine and 2 Department of Pharmacology, University of Illinois College of Medicine at Chicago, Chicago, Illinois 60612

Received 23 October 1996; accepted in final form 12 August 1997.

Carley, David W., Sinisa M. Trbovic, Alex Bozanich, and Miodrag Radulovacki. Cardiopulmonary control in sleeping Sprague-Dawley rats treated with hydralazine. J. Appl. Physiol. 83(6): 1954-1961, 1997.---To test the hypothesis that hydralazine can suppress spontaneous sleep-related central apnea, respiratory pattern, blood pressure, and heart period were monitored in Sprague-Dawley rats. In random order and on separate days, rats were recorded after intraperitoneal injection of 1) saline or 2) 2 mg/kg hydralazine. Normalized minute ventilation (NVI) declined significantly with transitions from wake to non-rapid-eye-movement (NREM) sleep (-5.1%; P = 0.01) and rapid-eye-movement (REM) sleep (-4.2%; P = 0.022). Hydralazine stimulated respiration (NVI increased by 21%; P < 0.03) and eliminated the effect of state on NVI. Blood pressure decreased by 17% after hydralazine, and the correlation between fluctuations in mean blood pressure and NVI changed from strongly positive during control recordings to weakly negative after hydralazine (P < 0.0001 for each). Postsigh and spontaneous apneas were reduced during NREM and REM sleep after hydralazine (P < 0.05 for each). This suppression was strongly correlated with the reduction in blood pressure and with the degree of respiratory stimulation. We conclude that mild hydralazine-induced hypotension leads to respiratory stimulation and apnea suppression.

baroreflex; sleep; hypotension; respiration; telemetry; apnea

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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